Medical device

Patent metadata

Field	Value
Publication number	US-2016303296-A1
Application number	US-201615193888-A
Country	US
Kind code	A1
Filing date	Jun 27, 2016
Priority date	Dec 27, 2013
Publication date	Oct 20, 2016
Grant date	—

Abstract

A medical device is provided including a base member and a coating layer containing an antithrombogenic material and covering a surface of the base member. The antithrombogenic material contains a copolymer having a repeating unit (A) represented by the following formula (1):

wherein R 11 is a hydrogen atom or a methyl group, Z is an oxygen atom or —NH—, R 12 is a C 1-6 alkylene group, R 13 and R 14 are each independently a C 1-4 alkyl group, and R 15 is a C 1-2 alkylene group, and a repeating unit (B) represented by the following formula (2):

wherein R 21 is a hydrogen atom or a methyl group, R 22 is a C 1-6 alkylene group, and R 23 is a C 1-4 alkyl group. The repeating unit (A) is contained in a proportion of 1 to 7 mol % based on all the structural units of the copolymer.

First claim

What is claimed is:

1 . A medical device, comprising:
a base member; and a coating layer containing an antithrombogenic material and at least partially covering a surface of the base member, wherein the antithrombogenic material comprises a copolymer comprising: a repeating unit (A) represented by the following formula (1):

wherein R 11 is a hydrogen atom or a methyl group, Z is an oxygen atom or —NH—, R 12 is a C 1-6 alkylene group, R13 and R14 are each independently a C 1-4 alkyl group, and R 15 is a C 1-2 alkylene group; and
a repeating unit (B) represented by the following formula (2):

wherein R 21 is a hydrogen atom or a methyl group, R 22 is a C 1-6 alkylene group, and R 23 is a C 1-4 alkyl group,
wherein the repeating unit (A) is contained in a proportion of 1 to 7 mol % based on all the structural units of the copolymer.

2 . The medical device according to claim 1 , wherein in the formula (2), R 21 is a hydrogen atom or a methyl group, R 22 is a C 1-3 alkylene group, and R 23 is a C 1-2 alkyl group.

3 . The medical device according to claim 1 , wherein in the formula (2), R 21 is a hydrogen atom, R 22 is a methylene group or an ethylene group, and R 23 is a methyl group.

4 . The medical device according to claim 3 , wherein in the formula (2), R 22 is an ethylene group.

5 . The medical device according to claim 1 , wherein in the formula (1), R 11 is a methyl group, Z is an oxygen atom, R 12 is a C 1-3 alkylene group, and R 13 and R 14 are each independently a C 1-2 alkyl group.

6 . The medical device according to claim 1 , wherein in the formula (1), R 11 is a methyl group, Z is an oxygen atom, R 12 is a methylene group or an ethylene group, and R 13 and R 14 are each a methyl group.

7 . The medical device according to claim 6 , wherein in the formula (1), R 15 is a methylene group.

8 . The medical device according to claim 1 , wherein in the formula (2), R 21 is a hydrogen atom or a methyl group, R 22 is a C 1-3 alkylene group, and R 23 is a C 1-2 alkyl group, and
wherein in the formula (1), R 11 is a methyl group, Z is an oxygen atom, R 12 is a C 1-3 alkylene group, and R 13 and R 14 are each independently a C 1-2 alkyl group.

9 . The medical device according to claim 1 , wherein the copolymer includes 1 to 7 mol % of the repeating unit (A) and 99 to 93 mol % of the repeating unit (B), based on all the structural units of the copolymer.

10 . The medical device according to claim 8 , wherein the copolymer includes 1 to 7 mol % of the repeating unit (A) and 99 to 93 mol % of the repeating unit (B), based on all the structural units of the copolymer.

11 . The medical device according to claim 1 , wherein the repeating unit (A) is contained in a proportion of 2 to 6 mol %, based on all the structural units of the copolymer.

12 . The medical device according to claim 1 , wherein the repeating unit (A) is contained in a proportion of 3 to 5 mol %, based on all the structural units of the copolymer.

13 . The medical device according to claim 1 , wherein the repeating unit (B) is contained in a proportion of 60 to 99 mol %, based on all the structural units of the copolymer.

14 . The medical device according to claim 1 , wherein the repeating unit (B) is contained in a proportion of 90 to 99 mol %, based on all the structural units of the copolymer.

15 . The medical device according to claim 1 , wherein the total amount of the repeating unit (A) and the repeating unit (B) is 100 mol %, based on all the structural units of the copolymer.

16 . The medical device according to claim 1 , wherein the antithrombogenic material further comprises a crosslinking agent, a thickener, a preservative, or a pH adjuster.

17 . The medical device according to claim 1 , wherein the base member comprises a polymer material, a metal, a ceramic, carbon, or a composite material thereof.

18 . The medical device according to claim 1 , wherein the surface of the base member is completely covered with the coating layer.

19 . The medical device according to claim 1 , wherein a thickness of the coating layer is 0.1 μm to 1 mm.

20 . The medical device according to claim 1 , wherein the medical device is an implantable prosthesis, an implantable treating instrument, an artificial organ for extracorporeal circulation, a catheter, or a guidewire.

Assignees

• Terumo Corp

Inventors

• Anzai Takao
• NISHIDA Kaori

Classifications

• A61L2300/604

  Biodegradation · CPC title

• A61L2300/606

  Coatings · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61L33/068

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (A61L33/062 takes precedence) · CPC title

• A61L2300/42

  Anti-thrombotic agents, anticoagulants, anti-platelet agents · CPC title