Composite particles, coated particles, method for producing composite particles, ligand-containing solid phase carrier and method for detecting or separating target substance in sample

Patent metadata

Field	Value
Publication number	US-11237162-B2
Application number	US-201716303941-A
Country	US
Kind code	B2
Filing date	May 23, 2017
Priority date	May 24, 2016
Publication date	Feb 1, 2022
Grant date	Feb 1, 2022

Abstract

The present invention relates to composite particles, coated particles, a method of producing composite particles, a ligand-containing solid phase carrier, and a method of detecting or separating a target substance in a sample. The above described composite particles each contains an organic polymer and inorganic nanoparticles, wherein the content of the inorganic nanoparticles in the composite particles is more than 80% by mass, and wherein the composite particles have a volume average particle size of from 10 to 1,000 nm.

First claim

The invention claimed is:

1. A method of producing composite particles, the method comprising:
mixing a magnetic fluid, a monomer and a polymerization initiator to prepare a monomer mixed liquid so that a content of magnetic nanoparticles is more than 80% by mass with respect to 100% by mass of a material for forming the composite particles in the monomer mixed liquid;
dispersing the monomer mixed liquid to prepare an emulsion; and
polymerizing the monomer in the emulsion to produce composite particles that comprise magnetic nanoparticles in an amount of more than 80% by mass.

2. The method of claim 1 , wherein the composite particles have a volume average particle size of from 10 to 1,000 nm.

3. The method of claim 1 , wherein the composite particles have a coefficient of variation of the volume average particle size of 20% or less.

4. The method of claim 1 , wherein the magnetic nanoparticles are present in an amount of more than 80% by mass to 95% by mass.

5. The method of claim 1 , wherein the magnetic nanoparticles have a volume average particle size of from 5 to 25 nm.

6. The method of claim 1 ,
wherein the magnetic fluid comprises at least one selected from the group consisting of a surfactant, an acid group-containing compound, an amino group-containing compound, a silane group-containing compound and a titanium atom-containing compound, and
wherein the composite particles comprise at least one selected from the group consisting of a surfactant, an acid group-containing compound, an amino group-containing compound, a silane group-containing compound and a titanium atom-containing compound.

7. The method of claim 1 , wherein the magnetic nanoparticles are metal oxide particles.

8. The method of claim 1 , wherein the monomer is a monomer such that the resulting polymer obtained is a hydrophobic polymer, and wherein the composite particles have surfaces to which at least one ligand can be physically adsorbed.

9. The method of claim 1 , wherein the monomer is a monomer containing a reactive functional group, and wherein the composite particles have surfaces to which at least one ligand can be chemically bound.

Assignees

• Jsr Corp
• Jsr Life Sciences Corp
• Jsr Life Sciences Llc
• Jsr Micro N V

Inventors

• Masuda Takeaki
• Onogi Shunsuke

Classifications

• H01F1/0063

  in a non-magnetic matrix, e.g. granular solids (granular films H01F10/007) · CPC title

• G01N33/545 Primary

  Synthetic resin · CPC title

• C08F12/06

  Hydrocarbons · CPC title

• G01N33/54326

  Magnetic particles · CPC title

• C08F220/06

  Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof · CPC title