Microfluidic interconnect
US-9791080-B2 · Oct 17, 2017 · US
US11221315B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11221315-B2 |
| Application number | US-201815947256-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 6, 2018 |
| Priority date | Apr 7, 2017 |
| Publication date | Jan 11, 2022 |
| Grant date | Jan 11, 2022 |
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A structural reinforcement and biocompatible pump head for a pump includes a reinforcement structure having a plurality of ports and fluid pathways therein. The fluid pathways in the reinforcement may be coated or lined with a biocompatible material to form a biocompatible pump head useful for liquid chromatography and other analytical instrument systems. The biocompatible material may be injection molded into the fluid pathways of the reinforcement structure and may be machined after core pins are removed to obtain a desired surface finish and/or size of the biocompatible fluid pathways of the pump head.
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We claim: 1. A biocompatible pump head for a pump comprising: a reinforcement body for a pump head having first and second ports therein, each port coupled with a fluid pathway extending between the ports and a chamber extending through the reinforcement body, the chamber configured at a first end to receive a portion of a pump, wherein each fluid pathway has a diameter that is smaller than a diameter of the chamber; and a biocompatible layer lining each of the fluid pathways and the chamber of said reinforcement body, the biocompatible layer plugging a second end of the chamber and forming a continuous surface between the chamber and a portion of each of the first and second ports, wherein any fluid flowing through the ports, the fluid pathways, and the chamber only contacts the biocompatible layer. 2. The biocompatible pump head for a pump according to claim 1 wherein said reinforcement body comprises stainless steel. 3. The biocompatible pump head for a pump according to claim 2 wherein said biocompatible layer comprises polyetheretherketone (PEEK). 4. The biocompatible pump head for a pump according to claim 3 wherein said pump head is able to withstand pressures of at least 5,000 psi. 5. The biocompatible pump head for a pump according to claim 3 wherein said pump head is able to withstand pressures of at least 10,000 psi. 6. The biocompatible pump head for a pump according to claim 3 wherein said pump head is able to withstand pressures of at least 15,000 psi. 7. The biocompatible pump head for a pump according to claim 3 wherein said pump head is able to withstand pressures of at least 20,000 psi. 8. An analytical instrument system comprising a pump, wherein said pump further comprises a pump head having a reinforcement body comprising a pump chamber extending therethrough and first and second ports coupled with respective first and second fluid pathways extending therethrough, each fluid pathway extending between the first and second ports and the pump chamber in the reinforcement body, wherein each fluid pathway has a diameter that is smaller than a diameter of the pump chamber, the pump chamber comprises a first end configured to receive a portion of a pump and a second end, and the reinforcement body further comprises a biocompatible layer lining each of the pump chamber and the first and second fluid pathways, the biocompatible layer plugging the second end of the pump chamber and forming a continuous surface between the pump chamber and a portion of each of the first and second ports, wherein any fluid flowing through the ports the fluid pathways, and the chamber only contacts the biocompatible layer. 9. The analytical instrument system according to claim 8 wherein said pump head is able to withstand pressures of at least 5,000 psi. 10. The analytical instrument system according to claim 8 wherein said pump head is able to withstand pressures of at least 10,000 psi. 11. The analytical instrument system according to claim 8 wherein said pump head is able to withstand pressures of at least 15,000 psi. 12. The analytical instrument system according to claim 8 wherein said pump head is able to withstand pressures of at least 20,000 psi. 13. The analytical instrument system according to claim 8 wherein said analytical instrument system comprises at least one of a liquid chromatography system, an ion chromatography system, a high pressure liquid chromatography system, an ultra high pressure liquid chromatography system, or a gas chromatography system. 14. A biocompatible pump head for a pump comprising: a reinforcement body for a pump head configured to withstand pressures of at least 5,000 psi and having first and second ports therein, each port coupled with a fluid pathway therethrough, the fluid pathways extending between the ports and a chamber extending through the reinforcement body, the chamber configured at a first end to receive a portion of a pump, wherein each fluid pathway has a diameter that is smaller than a diameter of the chamber and is configured to accommodate flow of a biocompatible material; and a biocompatible layer lining each of the fluid pathways and the chamber of said reinforcement body, the biocompatible layer plugging a second end of the chamber and forming a continuous surface between the chamber and a portion of each of the first and second ports, wherein any fluid flowing through the ports, the fluid pathways, and the chaniber only contacts the biocompatible layer. 15. The biocompatible pump head for a pump according to claim 14 , wherein said reinforcement body comprises stainless steel. 16. The biocompatible pump head for a pump according to claim 14 , wherein said biocompatible layer comprises polyetheretherketone (PEEK). 17. The biocompatible pump head for a pump according to claim 14 , wherein said pump head is able to withstand pressures of at least 10,000 psi. 18. The biocompatible pump head for a pump according to claim 14 , wherein said pump head is able to withstand pressures of at least 15,000 psi. 19. The biocompatible pump head for a pump according to claim 14 , wherein said pump head is able to withstand pressures of at least 20,000 psi.
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