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Method of using composition containing Hovenia dulcis Thunb. extract as active ingredient for prevention and treatment of bone diseases
US11219656B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11219656-B2 |
| Application number | US-201816111527-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 24, 2018 |
| Priority date | Mar 31, 2011 |
| Publication date | Jan 11, 2022 |
| Grant date | Jan 11, 2022 |
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- Title
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Abstract
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The invention relates to a composition containing extracts of the fruit of Hovenia dulcis Thunb., gallocatechin, and methyl vanillate as active ingredients for preventing and treating bone disease. The extracts of the fruit of Hovenia dulcis Thunb., the gallocatechin, and the methyl vanillate according to the present invention are natural materials and thus cause no side effects, and may activate the Wnt/β-catenin pathway to promote bone formation rather than inhibiting bone decomposition, and therefore may be effective in treating osteoporosis and related diseases. In addition, the extracts of the fruit of Hovenia dulcis Thunb., the gallocatechin, and the methyl vanillate according to the present invention may have the effects regrowing hair and preventing and treating wounds and metabolic diseases related to the activation of Wnt/β-catenin pathway.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method of treating a subject having an osteoporosis, the method comprising administering a composition comprising an effective amount of methyl vanillate as an active ingredient, wherein the methyl vanillate promotes a bone formation by activating a Wnt/β-catenin signaling pathway and inducing osteoblast differentiation. 2. The method of claim 1 , wherein the composition is administered via oral, parenteral, intraarterial, intradermal, transdermal, intramuscular, intraperitoneal, intravenous or subcutaneous routes.
Assignees
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Classifications
Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title
- A61K36/72Primary
Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree · CPC title
having an aromatic ring attached to a carboxyl group · CPC title
for osteoporosis · CPC title
3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title
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- What does patent US11219656B2 cover?
- The invention relates to a composition containing extracts of the fruit of Hovenia dulcis Thunb., gallocatechin, and methyl vanillate as active ingredients for preventing and treating bone disease. The extracts of the fruit of Hovenia dulcis Thunb., the gallocatechin, and the methyl vanillate according to the present invention are natural materials and thus cause no side effects, and may activa…
- Who is the assignee on this patent?
- Univ Yonsei Iacf
- What technology area does this patent fall under?
- Primary CPC classification A61K36/72. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).