Devices, systems, and methods for detecting substances

Patent metadata

Field	Value
Publication number	US-11207677-B2
Application number	US-201816225527-A
Country	US
Kind code	B2
Filing date	Dec 19, 2018
Priority date	Mar 7, 2018
Publication date	Dec 28, 2021
Grant date	Dec 28, 2021

Abstract

A microfluidic device for the detection of drugs, explosives, chemical warfare, or other substances which is able to directly accept a swab into the device for testing. This device additionally contains on-board reagents to perform colorimetric testing for threshold determination directly in the device. These features are useful in a wide array of situations, such as at security checkpoints, environmental monitoring, clinical analysis, which require testing completely unknown substances and therefore must test for multiple different substances in one test. This is especially useful for police and other law enforcement officials who often must use field-deployable platforms making accurate field-testing critical for safety.

First claim

We claim:

1. A microfluidic device for use with a swab and a solvent for colorimetric detection for substance identification, said microfluidic device comprising:
a microfluidic chip configured to spin;
a solvent capsule disposed on said microfluidic chip configured to contain said solvent;
a chamber well disposed on said microfluidic chip configured to receive said swab;
a microfluidic channel disposed on said microfluidic chip, and in fluidic communication with and between said solvent capsule and said chamber well;
said solvent capsule is configured to be able open when forces are applied to said solvent capsule to allow said solvent to escape from said solvent capsule;
said microfluidic channel is configured to allow said escaped solvent to travel via said microfluidic channel to interact with said swab, wherein said swab is intended to be positioned in said chamber well and remain separated from said solvent capsule; and
wherein said traveling of said escaped solvent to said swab via said microfluidic channel is a result of centrifugal forces exerted on said microfluidic chip as a result of said microfluidic chip spinning.

2. The microfluidic device of claim 1 , wherein said microfluidic chip is configured to accept a reagent.

3. The microfluidic device of claim 1 , wherein said microfluidic chip comprises a reagent chamber configured to hold a reagent.

4. The microfluidic device of claim 1 , wherein said microfluidic chip is configured to be able to allow a reagent to interact with a mixture containing said solvent.

5. The microfluidic device of claim 1 , further comprising a kit, wherein said kit includes said solvent contained in said solvent capsule.

6. The microfluidic device of claim 1 , further comprising a kit, wherein said kit includes said reagent contained in said reagent chamber.

7. The microfluidic device of claim 1 , further comprising a kit, wherein said kit includes said swab.

8. The microfluidic device of claim 1 , further comprising a kit, wherein said kit includes said solvent material, reagent material, and one or more swabs.

9. The microfluidic device of claim 1 , wherein a mating surface is disposed on said microfluidic device, said mating surface is configured to attach said swab to said microfluidic device.

10. The microfluidic device of claim 9 , wherein said mating surface is an adhesive material.

11. The microfluidic device of claim 1 , further comprising a handle configured for use with said swab.

12. The microfluidic device of claim 11 , wherein said handle is comprised of one or more of the following materials: 3D printed material, plastics, PVC, aluminum, or nylon.

13. The microfluidic device of claim 11 , wherein said handle is connected to a retainer.

14. The microfluidic device of claim 11 , further comprising a release mechanism that is connected to the handle, wherein said release mechanism is configured to assist in the release of said swab.

15. The microfluidic device of claim 14 , wherein said release mechanism comprises a spring.

16. The microfluidic device of claim 11 , further comprising an ejector mechanism connected to the handle, said ejector configured to assist in the release of said swab.

17. The microfluidic device of claim 16 , wherein said ejector mechanism is configured to attach to a plunger mechanism for releasing said swab from a retainer.

18. The microfluidic device of claim 1 , wherein said chamber well is disposed on said microfluidic chip.

19. The microfluidic device of claim 1 , wherein said chamber well is attached to said microfluidic chip.

20. The microfluidic device of claim 1 , wherein said chamber well is configured to substantially correspond with a shape of said swab.

21. The microfluidic device of claim 1 , wherein said chamber well is configured to substantially correspond with a shape of a retainer capable of holding said swab.

22. The microfluidic device of claim 1 , further comprising a manifold configured to attach to said microfluidic chip.

23. The microfluidic device of claim 1 , further comprising a manifold configured to be disposed on said microfluidic chip.

24. The microfluidic device of claim 23 , wherein said manifold has topography which is capable of interlocking with the topography of said microfluidic chip.

25. The microfluidic device of claim 23 , wherein said manifold includes an aperture wherein said aperture substantially corresponds to the shape of said swab.

26. The microfluidic device of claim 25 , wherein said manifold includes an aperture wherein said aperture substantially corresponds to the shape of a retainer capable of holding said swab.

27. The microfluidic device of claim 23 , further comprising said mating surface, wherein said mating surface is disposed on the microfluidic device inside of an aperture of said manifold.

28. The microfluidic device of claim 1 , wherein said solvent capsule is comprised of one or more of the following materials: glass, polymers, foil, or plastic.

29. The microfluidic device of claim 1 , further comprising a plurality of solvent capsules.

30. The solvent capsule of claim 29 , wherein said solvent capsule is configured to contain different solvents.

31. The microfluidic device of claim 1 , wherein the forces to open said solvent capsule is caused by human hands.

32. The microfluidic device of claim 1 , wherein the forces to open said solvent capsule is caused by a laser.

33. The microfluidic device of claim 1 , wherein the forces to open said solvent capsule is caused by being crushed or punctured by an outside device.

34. The microfluidic device of claim 1 , wherein said microfluidic device is configured to be able to test for trace presences of multiple substances in a single test.

35. The microfluidic device of claim 1 , wherein said microfluidic device is configured to be able to test a plurality of portions of said swab substantially simultaneously.

36. The microfluidic device of claim 1 , wherein said microfluidic device is configured to direct said solvent to different regions of said microfluidic chip, with said solvent passing through each of a plurality of said chamber wells being directed to a separate region on said chip.

37. The microfluidic device of claim 1 , further comprising a tracking feature disposed on said microfluidic device.

38. The microfluidic device of claim 7 , wherein said swab comprises two or more interface surface sections.

39. The microfluidic device of claim 1 , further comprising a plurality of chamber wells.

40. The microfluidic device of claim 1 , further comprising:
a sample prep chamber disposed on said microfluidic chip; and
a second microfluidic channel disposed on said microfluidic chip in fluid communication with said chamber well and said sample prep chamber, wherein said second microfluidic channel is between said chamber well and said sample prep chamber.

41. The microfluidic device of claim 40 , further comprising:
a reagent chamber or detection chamber disposed on said microfluidic chip; and
a third microfluidic channel disposed on said microfluidic chip in fluid communication with said sample prep chamber

Assignees

• Univ Virginia Patent Foundation

Inventors

• Krauss Shannon Theresa
• Landers James P

Classifications

• B01L3/502715 Primary

  characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces · CPC title

• G01N21/07

  Centrifugal type cuvettes (G01N21/09 takes precedence) · CPC title

• B01L2200/027

  for microfluidic devices · CPC title

• G01N21/78

  producing a change of colour · CPC title

• G01N2001/027

  field kits / quick test kits · CPC title