Frequency-based filtering of mechanical actuation using fluidic device

Patent metadata

Field	Value
Publication number	US-9987576-B2
Application number	US-201314650743-A
Country	US
Kind code	B2
Filing date	Dec 10, 2013
Priority date	Dec 10, 2012
Publication date	Jun 5, 2018
Grant date	Jun 5, 2018

Abstract

A mechanical input to a fluidic filter network can be actuated. The fluidic filter network can include respective branches fluidically coupling the mechanical input to respective deformable mechanical outputs. A mechanical displacement can be selectively coupled a selected deformable mechanical output of the fluidic filter network to a deformable mechanical input of a microfluidic device. A fluid flow in a portion of the microfluidic device can be controlled using the displacement, the selected deformable mechanical output can be selected at least in part by actuating the mechanical input to produce a displacement having energy in a specified range of frequencies, and the fluidic filter network is generally fluidically isolated from the microfluidic device.

First claim

The claimed invention is:

1. A method, comprising:
actuating a mechanical input to a closed fluidic filter network, the fluidic filter network comprising respective branches fluidically coupling the mechanical input to respective deformable mechanical outputs of the fluidic filter network, the respective deformable mechanical outputs located on an exterior surface of the fluidic filter network;
selectively transmitting a mechanical displacement from a selected deformable mechanical output of the fluidic filter network to a deformable mechanical input of a microfluidic device, the microfluidic device positioned on the exterior surface of the fluidic filter network;
controlling a fluid flow in a portion of the microfluidic device using the transmitted displacement;
wherein the selected deformable mechanical output is selected at least in part by actuating the mechanical input to produce a displacement having energy in a specified range of frequencies; and
wherein the fluidic filter network is fluidically isolated from the microfluidic device.

2. The method of claim 1 , wherein the actuating the mechanical input includes using an electrical-to-mechanical actuator coupled to a processor circuit, the processor circuit configured to control the electrical-to-mechanical actuator using instructions stored on a processor-readable medium.

3. The method of claim 1 , wherein the selectively transmitting the mechanical displacement includes placing the microfluidic device on or within a mechanical receptacle, the mechanical receptacle to align respective deformable mechanical outputs of the of the fluidic filter network with corresponding mechanical inputs of the microfluidic device.

4. The method of claim 1 , wherein controlling the fluid flow in the portion of the microfluidic device includes enhancing flow in a first fluid-filled branch of the fluidic filter network using a displacement provided by the actuating, the displacement having energy in a first range of frequencies.

5. The method of claim 4 , wherein controlling the fluid flow in the portion of the microfluidic device includes enhancing flow in a second fluid-filled branch of the fluidic filter network using a displacement provided by the actuating, the displacement having energy in a different second range of frequencies.

6. A system, comprising:
a closed fluidic filter network including:
a first fluid-filled branch fluidically coupling a mechanical input to a first deformable mechanical output; and
a second fluid-filled branch fluidically coupling the mechanical input to a second deformable mechanical output;
wherein the first fluid-filled branch is sized and shaped to transmit a mechanical displacement from the mechanical input to the first deformable mechanical output when the mechanical displacement includes energy in a first range of frequencies;
wherein the second fluid-filled branch is sized and shaped to couple a mechanical displacement from the mechanical input to the second deformable mechanical output when the mechanical displacement includes energy in a different second range of frequencies;
wherein the first deformable mechanical output and the second deformable mechanical output are located on an exterior surface of the fluidic filter network; and

a microfluidic device positioned on the exterior surface of the fluidic filter network, the microfluidic device comprising a fluidic channel including a deformable mechanical input coupled to a respective deformable mechanical output amongst the first and second deformable mechanical outputs of the fluidic filter network;
wherein a flow in the fluidic channel of the microfluidic device is controlled using a displacement transmitted from the respective deformable mechanical output of the fluidic filter network in response to a displacement provided at the mechanical input of the fluidic filter network, the microfluidic device fluidically isolated from the fluidic filter network.

7. The system of claim 6 , comprising an electrical-to-mechanical actuator mechanically coupled to the mechanical input to mechanically displace the mechanical input using energy having a specified range of frequencies.

8. The system of claim 7 , wherein the electrical-to-mechanical actuator comprises a voice-coil actuator.

9. The system of claim 8 , comprising a processor circuit coupled to the electrical-to-mechanical actuator to address a specified one or more of the first deformable mechanical output or the second deformable mechanical output by controlling the actuator to mechanically displace the mechanical input using energy having the specified range of frequencies.

10. The system of claim 6 , wherein the microfluidic device includes a fluidic diode.

11. The system of claim 10 , wherein the microfluidic device comprises respective deformable mechanical inputs coupled to respective deformable mechanical outputs of the fluidic filter network; and
wherein the respective deformable mechanical inputs are selectively addressable for transmitting a displacement selectively to a selected one or more deformable mechanical inputs using the fluidic filter network.

12. The system of claim 10 , wherein the microfluidic device comprises at least one compliant layer and at least one rigid layer.

13. The system of claim 12 , wherein the rigid layer includes glass, and wherein the compliant layer includes PDMS.

14. The system of claim 10 , a mechanical receptacle configured to mechanically couple the microfluidic device to the fluidic filter network when the microfluidic device is inserted in the mechanical receptacle.

15. The system of claim 6 , wherein the first and second branches have different lengths, and wherein the first and second ranges of frequencies are established at least in part by the respective different lengths.

16. The system of claim 6 , wherein the first and second fluid-filled branches comprise channels formed in a rigid material; and
wherein the first and second deformable mechanical outputs comprise respective deformable membranes.

17. The system of claim 6 , wherein the first and second deformable mechanical outputs and the mechanical input comprise respective deformable membranes.

18. A system, comprising:
a closed fluidic filter network respective fluid-filled branches fluidically coupling a mechanical input to respective deformable mechanical outputs, the respective deformable mechanical outputs located on an exterior surface of the fluidic filter network;
an electrical-to-mechanical actuator mechanically coupled to the mechanical input to mechanically displace the mechanical input using energy having a specified range of frequencies;
a removable microfluidic device including respective deformable mechanical inputs coupled to respective deformable mechanical outputs of the fluidic filter network;
wherein the respective deformable mechanical inputs are selectively addressable for transmitting a displacement selectively to a selected one or more deformable mechanical inputs using the fluidic filter network;
wherein a flow in a specified portion of the microfluidic device is controlled using a displacement transmitted from a selected deformable mechanical output of the fluidic filter network to a respective deformable mechanical input of the microfluidic device in response to a displacement coupled to the mechanical input of the fluidic filter network having energy in a specified range of frequencies; and
wherein the fluidic filter network is fluidically isolated from the microfluidic device at least in part using the respective deformable mech

Assignees

• Univ Virginia Patent Foundation
• Univ California

Inventors

• Landers James P
• Begley Matthew R

Classifications

• B01L3/502738 Primary

  characterised by integrated valves (throttle valves in microfluidic sample containers B01L3/502746) · CPC title

• B01L2300/0816

  Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title

• F16K99/0028

  Valves having multiple inlets or outlets · CPC title

• B01L3/502715

  characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces · CPC title

• B01D35/1573 Primary

  Flow control valves · CPC title