System and method for locally correlated spectroscopy for assessing medical discorders

Patent metadata

Field	Value
Publication number	US-11181594-B2
Application number	US-201515526883-A
Country	US
Kind code	B2
Filing date	Nov 13, 2015
Priority date	Nov 13, 2014
Publication date	Nov 23, 2021
Grant date	Nov 23, 2021

Abstract

Systems and methods for analyzing metabolite concentration in a subject using a medical imaging system are provided. The method includes, using a nuclear magnetic resonance (NMR] system, acquiring data from a subject during multiple acquisitions using different echo times for the multiple acquisitions to create a chemical shift domain. The method also includes, using the chemical shift domain, identifying metabolites by at least two chemical shifts and generating a report indicating the metabolites.

First claim

The invention claimed is:

1. A method for analyzing metabolite concentration in a subject using a medical imaging system, the method comprising:
using a nuclear magnetic resonance (NMR) system, acquiring data from a subject during multiple acquisitions using different echo times for the multiple acquisitions to create a chemical shift domain;
using the chemical shift domain, identifying metabolites at least including tyrosine or phenylalanine by at least two chemical shifts for each metabolite; and
generating a report indicating the metabolites at least including tyrosine levels or phenylalanine.

2. The method of claim 1 wherein identifying the metabolites by the at least two chemical shifts corresponding to different proton groups in the subject.

3. The method of claim 1 wherein the report indicates a concentration of the metabolites in three dimensions.

4. The method of claim 1 wherein using the NMR system to acquire the data includes acquiring two-dimensional (2D) spectroscopy data from the subject.

5. The method of claim 4 wherein using the NMR system to acquire the data includes acquiring one-dimensional (1D) spectroscopy data from the subject.

6. The method of claim 5 wherein a concentration of a given metabolite calculated from the 1D spectroscopy data is used as a reference to normalize the 2D spectroscopy data.

7. The method of claim 6 wherein at least one of the 2D spectroscopy data is acquired using a COSY pulse sequence or the 1D spectroscopy data is acquired using a PRESS pulse sequence.

8. The method of claim 1 further comprising acquiring anatomical data of the subject and using the anatomical data to quantify an absolute metabolite concentration in a selected volume within the subject.

9. The method of claim 8 wherein the NMR system includes a magnetic resonance imaging (MRI) system and wherein the anatomical data is acquired using the MRI system.

10. The method of claim 1 wherein the report includes an absolute quantification of the metabolites at least including tyrosine levels or phenylalanine.

11. A method for analyzing metabolite concentration in a subject using a medical imaging system, the method comprising:
using a magnetic resonance imaging (MRI) system, acquiring one-dimensional (1D) spectroscopy data from a subject;
using the MRI system, acquiring two-dimensional (2D) spectroscopy data from the subject during multiple acquisitions using different echo times for the multiple acquisitions to create a chemical shift domain;
using the chemical shift domain, identifying metabolites by at least two chemical shifts for each metabolite; and
generating a report indicating the metabolites in three dimensions, wherein an absolute concentration of the metabolites is indicated in one dimension.

12. The method of claim 1 , further comprising using a nuclear magnetic resonance (NMR) system, to acquire one-dimensional (1D) spectroscopy data from a subject.

13. The method of claim 12 wherein acquiring the 1D spectroscopy data includes performing a first pulse sequence using the MRI system and acquiring the 2D spectroscopy data includes performing a second pulse sequence using the MRI system, wherein the first pulse sequence and the second pulse sequence are different pulse sequences.

14. The method of claim 13 wherein the second pulse sequence includes a two-dimensional shift correlated MR spectroscopy (COSY) pulse sequence.

15. The method of claim 1 wherein using the chemical shift domain to identify metabolites at least including tyrosine or phenylalanine by at least two chemical shifts for each metabolite includes assessing a concentration of the metabolite in a third dimension of the chemical shift domain.

16. The method of claim 11 wherein acquiring the 1D spectroscopy data includes performing a first pulse sequence using the MRI system and acquiring the 2D spectroscopy data includes performing a second pulse sequence using the MRI system, wherein the first pulse sequence and the second pulse sequence are different pulse sequences.

17. The method of claim 16 wherein the second pulse sequence includes a two-dimensional shift correlated MR spectroscopy (COSY) pulse sequence.

18. The method of claim 11 wherein using the chemical shift domain to identify metabolites at least including tyrosine or phenylalanine by at least two chemical shifts for each metabolite includes assessing a concentration of the metabolite in a third dimension of the chemical shift domain.

Assignees

• Brigham & Womens Hospital Inc
• Boston Childrens Hospital
• Childrens Medical Center

Inventors

• Lin Alexander
• Waisbren Susan

Classifications

• G01R33/485

  based on chemical shift information {[CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites} · CPC title

• G01R33/465

  applied to biological material, e.g. in vitro testing · CPC title

• G01N2570/00

  Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes · CPC title

• G01N2500/10

  involving cells · CPC title

• G01N33/5038

  involving detection of metabolites per se · CPC title