Methods for preventing or mitigating acute allergic responses using human milk oligosaccharides

Patent metadata

Field	Value
Publication number	US-11135233-B2
Application number	US-201916730139-A
Country	US
Kind code	B2
Filing date	Dec 30, 2019
Priority date	Nov 19, 2013
Publication date	Oct 5, 2021
Grant date	Oct 5, 2021

Abstract

A method for preventing or mitigating an acute allergic response in a subject is disclosed. The method includes a step of administering a nutritional composition to the subject. The nutritional composition includes at least one of an acidic or a neutral HMO, but does not include an N-acetyl-lactosamine.

First claim

We claim:

1. A method for reducing the severity of an allergic response in a subject in need thereof, the method comprising administering a nutritional composition to the subject, wherein the nutritional composition comprises a human milk oligosaccharide (HMO) component, the HMO component selected from the group consisting of fucosylated oligosaccharides, sialylated oligosaccharides, or a combination thereof;
wherein the allergic response comprises one or more mast cell mediated immediate allergic responses.

2. The method of claim 1 , wherein the HMO component consists of a neutral HMO which is 2′-fucosyllactose (2′-FL) and an acidic HMO which is 6′-sialyllactose (6′-SL), and the one or more mast cell mediated immediate allergic response is selected from the group consisting of a skin mast cell response, a gastrointestinal mast cell response, and a respiratory mast cell response.

3. The method of claim 1 , wherein the HMO component comprises either 2′-FL or 6′-SL, but not both.

4. The method of claim 1 , wherein the HMO component comprises 2′-FL, 6′-SL, or both, and the nutritional composition is administered to the subject to mitigate an allergic response comprising more than one mast cell mediated immediate allergic response.

5. The method of claim 1 , wherein the HMO component includes 2′-FL, 6′-SL, or both in an amount of 0.001 mg/mL to 20 mg/mL.

6. The method of claim 3 , wherein a nutritional composition comprising 2′-FL is administered to the subject to mitigate one mast cell mediated immediate allergic response.

7. The method of claim 3 , wherein a nutritional composition comprising either 2′-FL or 6′-SL is administered to the subject to mitigate a skin mast cell response.

8. The method of claim 3 , wherein a nutritional composition comprising 2′-FL is administered to the subject to mitigate a gastrointestinal mast cell response.

9. The method of claim 4 , wherein a nutritional composition comprising both 2′-FL and 6′-SL is administered to the subject to mitigate an acute allergic response.

10. The method of claim 6 , wherein the nutritional composition further comprises at least one of a protein source, a carbohydrate source, and a fat source.

11. The method of claim 6 , further comprising administering an antihistamine to the subject.

12. The method of claim 11 , wherein the antihistamine comprises a compound selected from the group consisting of loratadine, fexofenadine, and cetirizine.

13. The method of claim 6 , further comprising administering an eicosanoid inhibitor to the subject.

14. The method of claim 6 , wherein the nutritional composition further comprises a carbohydrate selected from the group consisting of maltodextrin, corn syrup solids, and sucrose.

15. The method of claim 6 , wherein the nutritional composition further comprises a hypoallergenic form of galacto-oligosaccharide.

16. A method for mitigating an immediate type allergic response in a subject in need thereof, the method comprising administering a nutritional composition to the subject, wherein the nutritional composition comprises a human milk oligosaccharide (HMO) component, the HMO component selected from the group consisting of fucosylated oligosaccharides, sialylated oligosaccharides, or a combination thereof.

17. The method of claim 16 , wherein the fucosylated oligosaccharide is 2′-FL and the sialylated oligosaccharide is 6′-SL.

18. The method of claim 17 , wherein a nutritional composition comprising both 2′-FL and 6′-SL is administered to the subject to mitigate an acute allergic response.

19. A method for reducing the severity of an allergic response in a subject in need thereof, the method comprising administering a nutritional composition to the subject, wherein the nutritional composition comprises a human milk oligosaccharide (HMO) component, the HMO component selected from the group consisting of 2′-FL, 6′-SL, or a combination thereof, wherein the human milk oligosaccharide is present in an amount effective to increase antigen exposure levels required to trigger an allergic response; wherein the allergic response comprises one or more mast cell mediated immediate allergic responses.

Assignees

• Abbott Lab

Inventors

• Buck Rachael
• Davis Steven
• Forsythe Paul

Classifications

• A23V2250/00

  Food ingredients · CPC title

• A23L5/00

  Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor · CPC title

• A61K31/7016

  Disaccharides, e.g. lactose, lactulose (lactobionic acid A61K31/7032) · CPC title

• A61K31/4545

  containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine · CPC title

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title