Method of using hydrophilized bactericidal polymers

Patent metadata

Field	Value
Publication number	US-11134684-B2
Application number	US-201615163285-A
Country	US
Kind code	B2
Filing date	May 24, 2016
Priority date	Aug 24, 2005
Publication date	Oct 5, 2021
Grant date	Oct 5, 2021

Abstract

A bactericidal polymeric composition includes a hydrophilic first comonomer copolymerized to a second comonomer to produce a polymeric composition that is more hydrophilic or more bactericidal in an aqueous solution than either of the comonomers alone. Methods for identifying bactericidal polymers, methods for rendering materials bactericidal, and methods for using bactericidal compositions to kill or reduce bacterial growth are also described. Applications for the inventive compositions include their use in catheters, stents, medical devices, contact lenses; root canal fillers; and/or wound dressings.

First claim

What is claimed is:

1. A method of rendering a material bactericidal comprising adding a copolymer consisting essentially of a first comonomer that is hydrophilic and a second comonomer that is bactericidal to a medium, wherein
a. the copolymer is a random copolymer which is more bactericidal than the first comonomer alone or the bactericidal second comonomer alone;
b. the first comonomer comprises a poly(ethylene glycol) ester of an acrylate or a methacrylate moiety;
c. the second comonomer comprises a 4-vinyl pyridine;
d. the second comonomer is quaternized with an alkyl group so that the random copolymer contains quaternized second comonomer; and
e. the quaternized second comonomer is cationic.

2. The method of claim 1 , wherein the first comonomer has a molecular weight between about 300 and about 2000.

3. The method of claim 2 , wherein the first comonomer comprises the poly(ethylene glycol) ester of the methacrylate moiety.

4. The method of claim 3 , wherein the first comonomer has a molecular weight of about 1100.

5. The method of claim 4 , wherein the alkyl group comprises hexyl.

6. The method of claim 5 , wherein the copolymer contains less than or equal to about 99 mole percent of said second comonomer.

7. The method of claim 6 , wherein the copolymer contains less than or equal to about 95 mole percent of said second comonomer.

8. The method of claim 7 , wherein the copolymer contains less than or equal to about 75 mole percent of said second comonomer.

9. The method of claim 8 , wherein the copolymer contains less than or equal to about 50 mole percent of said second comonomer.

10. The method of claim 9 , wherein the copolymer contains less than or equal to about 25 mole percent of said second comonomer.

11. The method of claim 10 , wherein the copolymer contains less than or equal to about 10 mole percent of said first comonomer.

12. The method of claim 2 , wherein the alkyl group comprises hexyl.

13. The method of claim 12 , wherein the medium is an aqueous liquid.

14. The method of claim 12 , wherein the medium is an object touched by people that reduces transmission of bacterial infections.

15. The method of claim 14 , wherein the object is formed by applying an unquaternized copolymer consisting essentially of said first comonomer and said second comonomer to the medium and subsequently quaternizing the unquaternized copolymer with the alkyl group.

16. The method of claim 12 , wherein the copolymer contains less than or equal to about 99 mole percent of said second comonomer.

17. The method of claim 16 , wherein the copolymer contains less than or equal to about 95 mole percent of said second comonomer.

18. The method of claim 17 , wherein the copolymer contains less than or equal to about 75 mole percent of said second comonomer.

19. The method of claim 18 , wherein the copolymer contains less than or equal to about 50 mole percent of said second comonomer.

20. The method of claim 19 , wherein the copolymer contains less than or equal to about 25 mole percent of said second comonomer.

21. The method of claim 12 , wherein the copolymer contains less than or equal to about 10 mole percent of said first comonomer.

Assignees

• Purdue Research Foundation

Inventors

• Youngblood Jeffrey P
• Sellenet Philippe H

Classifications

• C08F220/286 Primary

  and containing polyethylene oxide in the alcohol moiety, e.g. methoxy polyethylene glycol (meth)acrylate · CPC title

• A01N43/40 Primary

  six-membered rings · CPC title

• C12Q1/18

  Testing for antimicrobial activity of a material · CPC title

• C08F226/08

  N-Vinyl-pyrrolidine · CPC title

• C08F220/281

  and containing only one oxygen, e.g. furfuryl (meth)acrylate or 2-methoxyethyl (meth)acrylate · CPC title