Antimicrobial amorphous compositions

Patent metadata

Field	Value
Publication number	US-9289378-B2
Application number	US-66323605-A
Country	US
Kind code	B2
Filing date	Sep 19, 2005
Priority date	Sep 20, 2004
Publication date	Mar 22, 2016
Grant date	Mar 22, 2016

Abstract

The present invention comprises compositions and methods for providing antimicrobial compositions. The antimicrobial compositions comprise gel delivery vehicles comprising stabilized silver, wherein ionic silver is provided to a site for antimicrobial purposes. Methods of making and using such compositions are taught, including application of the silver-containing gel compositions to wounds, burns, abrasions, cuts, surgical incision, sites where skin or organ integrity has been breached, and other sites to supply an antimicrobial environment.

First claim

What is claimed is:

1. An antimicrobial composition, comprising an amorphous delivery vehicle composition, a stabilized silver salt, wherein the stabilized silver salt comprises silver saccharinate, wherein the stabilized silver salt is stabilized by a molar excess of saccharinate anions to silver ions, wherein the antimicrobial composition is spreadable and resistant to discoloration due to light exposure.

2. The composition of claim 1 , further comprising an oxidizing agent.

3. The composition of claim 2 , wherein the oxidizing agent comprises copper, zinc or iron compounds, hydrogen peroxide or zinc peroxide.

4. The composition of claim 1 , further comprising an active agent.

5. The composition of claim 1 , wherein the delivery vehicle comprises a polymeric composition comprising an aqueous composition of an alkylcellulose derivative, sodium carboxycellulose, carboxymethylcellulose, hydroxyethylcellulose, or hydroxypropyl cellulose.

6. The composition of claim 1 , wherein the delivery vehicle comprises a water-in-oil or oil-in-water emulsion.

7. The composition of claim 1 , wherein the delivery vehicle comprises a hydrogel, a gel, a jelly, a lotion, an ointment, an emulsion, or a cream.

8. The composition of claim 1 , wherein the delivery vehicle comprises propylene glycol, polyethylene glycol of different molecular weights, cellulose ethers such as hydroxymethyl, hydroxyethyl and other higher alkyl derivatives, lactic acid, polyquaternary ammonium polymers known as polyquats, triethanol amine, carbomer polymers of various grades, aminoethyl propanol, di or tetra sodium EDTA, polyvinylpyrrolidone, PVP/Vinyl Acetate copolymer, polyoxyethylene-polyoxypropylene copolymers, sorbitol, poly(n-isopropylacrylamide) polymers, glyceryl polymethacrylates or other acrylates, poly(methacrylic acid), dimethicone copolyols, siloxane polymers with polyethylene glycols side chains, polyvinyl alcohol, polyethylene oxide polymers, poly(vinyl acetate co-vinyl alcohol), cellulose ethers, hydroxyalkyl cellulose with alkyl groups methyl, ethyl or propyl, sodium carboxymethyl cellulose, sodium alginate modified with small amounts of calcium or magnesium ions, propylene glycol ester or glyceryl ester of alginic acid, gum karaya, guar gum, gum acacia or gum tragacanth, hydratable polyurethane polymers, polyalkylene polymers, alginates, naturally occurring polymers and derivatives, hyaluronic acid and derivatives, microbial polysaccharides, beta-1,3 glucan polysaccharide, acetoacetylated high molecular weight poly vinyl alcohol and hydroxyalkyl cellulose derivatives, xanthan gum, locust bean gum, beta-cyclodextrin derivatives or block copolymers having the general formula xB-[AB]n-yA wherein n is an integer ≧1, x and y are 0 or 1, and y is 1 when n is 1, A is a thermoplastic hydrophobic polymer block, and B is a thermoplastic hydrophilic polymer block.

9. The composition of claim 1 , further comprising an electron acceptor, wherein the electron acceptor comprises cupric chloride, ferric chloride, zinc chloride, gold, platinum, or cesium.

10. A method of making an antimicrobial amorphous silver salt composition, comprising, combining, in no particular order, delivery vehicle composition components with silver salt composition components to produce an amorphous delivery vehicle comprising a stabilized silver salt, wherein the stabilized silver salt comprises silver saccharinate, wherein the stabilized silver salt is stabilized by a molar excess of saccharinate anions to silver ions, and wherein the antimicrobial composition is spreadable and resistant to discoloration due to light exposure.

11. The method of claim 10 , wherein the delivery vehicle composition is preformed or prepared first, followed by adding a stabilizing agent to the delivery vehicle composition, and then mixing the delivery vehicle composition with a silver salt solution.

12. The method of claim 10 , wherein the delivery vehicle composition is preformed or prepared first, followed by, adding in no particular order, an anionic solution and a cationic silver solution to form a silver salt in situ in the delivery vehicle composition.

13. The method of claim 10 , further comprising adding an oxidizing agent, wherein the oxidizing agent comprises copper, zinc or iron compounds, hydrogen peroxide or zinc peroxide.

14. The method of claim 10 , further comprising adding an active agent.

15. The method of claim 10 , wherein the delivery vehicle is an emulsion, and the method comprises combining a water phase component of the emulsion comprising a silver salt; and adding the water phase to an oil phase to form an antimicrobial amorphous composition.

16. A method of treating or reducing microbial growth or adherence, comprising, applying an amorphous silver salt composition comprising an antimicrobially effective amount of a stabilized silver salt to a surface, wherein the stabilized silver salt comprises silver saccharinate, wherein the stabilized silver salt is stabilized by a molar excess of saccharinate anions to silver ions, and wherein the antimicrobial composition is spreadable and resistant to discoloration due to light exposure.

17. The method of claim 16 , wherein the surface is a body site where loss of skin or organ integrity has occurred.

18. The method of claim 16 , wherein the surface is a burn or wound.

Assignees

• Karandikar Bhalchandra M
• Gibbins Bruce L
• Avent Inc

Inventors

• Karandikar Bhalchandra M
• Gibbins Bruce L

Classifications

• A61P31/04

  Antibacterial agents · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61K47/38

  Cellulose; Derivatives thereof · CPC title

• A61K47/06

  Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite · CPC title

• A61K31/28

  Compounds containing heavy metals · CPC title