Method for producing fine, hollow projection tool

Patent metadata

Field	Value
Publication number	US-11123530-B2
Application number	US-201716073174-A
Country	US
Kind code	B2
Filing date	Jan 17, 2017
Priority date	Jan 27, 2016
Publication date	Sep 21, 2021
Grant date	Sep 21, 2021

Abstract

Method for manufacturing fine hollow protruding tool by: bringing a projecting mold part with a heating means into contact from one surface side of a base sheet including a thermoplastic resin, and, while heat-softening the contact section, inserting the projecting mold part into the base sheet, to form a protrusion protruding from the other surface side; and, after a cooling step, withdrawing the projecting mold part from the interior of the protrusion, forming the fine hollow protruding tool. In the protrusion forming step, the protrusion is formed by using a first warp-suppressing means that suppresses warping of the base sheet when the projecting mold part is inserted into the base sheet. In the release step, the fine hollow protruding tool is formed by using a second warp-suppressing means that suppresses warping of the base sheet when the projecting mold part is withdrawn from the interior of the protrusion.

First claim

The invention claimed is:

1. A method for manufacturing a hollow protruding tool having a hollow interior, the method comprising:
a protrusion forming step of
bringing a projecting mold part that includes a heating means into contact from a first surface side of a base sheet including a thermoplastic resin, and,
while softening, with heat, a contact section in the base sheet where the projecting mold part contacts the base sheet, inserting the projecting mold part into the base sheet, to form a protrusion that protrudes from a second surface side of the base sheet;
a cooling step of cooling the protrusion in a state where the projecting mold part is inserted in an interior of the protrusion; and
a release step of withdrawing the projecting mold part from the interior of the protrusion after the cooling step, to form the hollow protruding tool, wherein:
in the protrusion forming step, the protrusion is formed by using a first warp-suppressing means that suppresses warping of the base sheet when the projecting mold part is inserted into the base sheet;
in the release step, a second warp-suppressing means that suppresses warping of the base sheet when the projecting mold part is withdrawn from the interior of the protrusion is used; and
in the protrusion forming step, the contact section of the base sheet is heated to a temperature from equal to or higher than the glass transition temperature of the base sheet to below the melting temperature of the base sheet by heating with the projecting mold part, and other regions of the base sheet are heated to a temperature below the glass transition temperature or are not heated; and
wherein the heating means of the projecting mold part is an ultrasonic vibration device,
wherein said protrusion is a microneedle, and
wherein said hollow protruding tool is a microneedle array in which a plurality of the protrusions are arranged on the base sheet.

2. The method for manufacturing a hollow protruding tool according to claim 1 , wherein the first warp-suppressing means is arranged on the second surface side of the base sheet, and the first warp-suppressing means is a support that supports the base sheet when the projecting mold part is inserted into the base sheet.

3. The method for manufacturing a hollow protruding tool according to claim 2 , wherein:
the second warp-suppressing means is arranged on the first surface side of the base sheet, and the second warp-suppressing means is a second support that supports the base sheet when the projecting mold part is withdrawn from the base sheet; and
the protrusion forming step is performed in a state where the base sheet is sandwiched between the second support and the support of the protrusion forming step.

4. The method for manufacturing a hollow protruding tool according to claim 3 , wherein at least one of the support and the second support supports a region other than a region, in the base sheet, where the protrusion is formed.

5. The method for manufacturing a hollow protruding tool according to claim 3 , wherein at least one of the support and the second support is an opening plate including a plurality of openings into which projecting molds of the projecting mold part can be inserted.

6. The method for manufacturing a hollow protruding tool according to claim 5 , wherein the opening plate is formed such that one of the projecting molds is passed through one of the openings.

7. The method for manufacturing a hollow protruding tool according to claim 3 , wherein at least one of the support and the second support initially has no opening for allowing a projecting mold of the projecting mold part to pass therethrough, and an opening is formed by being pressed by the projecting mold part being inserted into the base sheet in the protrusion forming step.

8. The method for manufacturing a hollow protruding tool according to claim 2 , wherein:
the second warp-suppressing means is a suction port arranged in the support; and
in the release step, warping of the base sheet is suppressed by using the suction port to suck the base sheet from the second surface side when the projecting mold part is withdrawn from the base sheet.

9. The method for manufacturing a hollow protruding tool according to claim 1 , wherein the shape of the hollow protruding tool is controlled by controlling at least one condition selected from: a condition of the heating means of the projecting mold part, an insertion height of the projecting mold part into the base sheet, a softening time of the contact section of the base sheet, and an insertion speed of the projecting mold part into the base sheet in the protrusion forming step; the shape of the projecting mold part; and a cooling condition in the cooling step.

10. The method for manufacturing a hollow protruding tool according to claim 1 , wherein:
a continuous base sheet is used as the base sheet; and
the hollow protruding tool is formed continuously on the second surface side of the continuous base sheet.

11. The method for manufacturing a hollow protruding tool according to claim 1 , wherein the heating temperature of the base sheet by heating with the projecting mold part is equal to or higher than the glass transition temperature of the base sheet to below the melting temperature thereof.

12. The method for manufacturing a hollow protruding tool according to claim 1 , wherein:
the contact section is softened by causing ultrasonic vibration of the projecting mold part by the ultrasonic vibration device and generating heat in the contact section by friction.

13. The method for manufacturing a hollow protruding tool according to claim 12 , wherein the frequency of the ultrasonic vibration is from 10 to 50 kHz.

14. The method for manufacturing a hollow protruding tool according to claim 13 , wherein the amplitude of the ultrasonic vibration is from 1 to 60 μm.

15. The method for manufacturing a hollow protruding tool according to claim 1 , wherein a temperature equal to or above the softening temperature of the base sheet is applied only to a section of the base sheet where the projecting mold part is inserted, and a region in the vicinity thereof; and in the other regions of the base sheet, temperature rise is left only to natural progression.

16. The method for manufacturing a hollow protruding tool according to claim 1 , wherein the height of a projecting mold of the projecting mold part is formed equal to or slightly higher than the height of the hollow protruding tool being manufactured.

17. The method for manufacturing a hollow protruding tool according to claim 1 , wherein the height of a projecting mold of the projecting mold part is from 0.01 to 30 mm.

18. The method for manufacturing a hollow protruding tool according to claim 17 , wherein a tip end diameter of the projecting mold part is from 0.001 to 1 mm.

19. The method for manufacturing a hollow protruding tool according to claim 18 , wherein a base diameter of a projecting mold of the projecting mold part is from 0.1 to 5 mm.

20. The method for manufacturing a hollow protruding tool according to claim 19 , wherein a tip end angle of the projecting mold part is from 1 to 60 degrees.

21. The method for manufacturing a hollow protruding tool according to claim 1 , wherein, in the cooling step, cooling is applied by blowing cold air in a state where the projecting mold part is inserted in the interior of the protrusion.

22. The method for manufacturing a hollow protruding tool according to claim 21 ,

Assignees

• Kao Corp

Inventors

• Niitsu Takatoshi
• Ueno Satoshi

Classifications

• A61M37/00

  Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title

• A61M2037/0053

  Methods for producing microneedles · CPC title

• A61M2207/10

  Device therefor · CPC title

• B81C1/00111

  Tips, pillars, i.e. raised structures (microneedles A61M37/0015) · CPC title

• B81C2201/034

  Moulding · CPC title