Alpha helix cell-penetrating peptide multimer, preparation method therefor and use therefor
US-2016229894-A1 · Aug 11, 2016 · US
Broken or folded helical peptide or peptide analog exhibiting antimicrobial activity against gram-negative bacteria, and use thereof
US11123400B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11123400-B2 |
| Application number | US-201615761089-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 19, 2016 |
| Priority date | Sep 17, 2015 |
| Publication date | Sep 21, 2021 |
| Grant date | Sep 21, 2021 |
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- Title
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- Abstract
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Abstract
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The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for killing Gram-negative bacteria, comprising administering i) a Gram-negative bacterial membrane-penetrating peptide comprising the sequence of SEQ ID NO: 14, 19, 22 or 30 and ii) an antibiotic, wherein the antibiotic has an antimicrobial activity for Gram-positive bacteria. 2. The method of claim 1 , wherein the antibiotic having an antimicrobial activity for Gram-positive bacteria is cloxacillin or linezolid. 3. A method for killing Gram-negative bacteria, comprising administering i) a Gram-negative bacterial membrane-penetrating peptide comprising the sequence of SEQ ID NO: 14, 19, 22 or 30 and ii) a drug, wherein the drug is resveratrol, curcumin, ibuprofen, quercetin, simvastatin, lovastatin or atorvastatin.
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Classifications
Drugs for disorders of the cardiovascular system · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
Peptides having 12 to 20 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title
Antibacterial agents · CPC title
Phenols {(cannabinoids A61K31/658)} · CPC title
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- What does patent US11123400B2 cover?
- The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific …
- Who is the assignee on this patent?
- Seoul Nat Univ R&Db Foundation
- What technology area does this patent fall under?
- Primary CPC classification A61K38/16. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).