HPV particles and uses thereof
US-10688172-B2 · Jun 23, 2020 · US
Virus-like particle conjugates for diagnosis and treatment of tumors
US11110181B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11110181-B2 |
| Application number | US-202016778361-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 31, 2020 |
| Priority date | Sep 18, 2013 |
| Publication date | Sep 7, 2021 |
| Grant date | Sep 7, 2021 |
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- Title
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Abstract
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The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
First claim
Opening claim text (preview).
What is claimed is: 1. A tumor-targeting virus-like particle comprising papilloma virus capsid proteins and 50 to 1000 photosensitive molecules conjugated to the capsid proteins, wherein the photosensitive molecules comprise (a) a photosensitive molecule that becomes toxic or produces a toxic molecule upon activation by light and (b) a photosensitive molecule that does not become toxic or produce a toxic molecule upon activation by light. 2. The virus-like particle of claim 1 , wherein the papilloma virus capsid proteins are non-human papilloma virus capsid proteins. 3. The virus-like particle of claim 2 , wherein the non-human papilloma virus capsid proteins comprise L1 capsid proteins. 4. The virus-like particle of claim 3 , wherein the non-human papilloma virus capsid proteins consist of L1 capsid proteins. 5. The virus-like particle of claim 1 , wherein the photosensitive molecules are covalently conjugated to the capsid proteins. 6. A method comprising delivering to a subject a tumor-tropic virus-like particle comprising papilloma virus capsid proteins and 50 to 1000 photosensitive molecules conjugated to the capsid proteins, wherein the photosensitive molecules comprise (a) a photosensitive molecule that becomes toxic or produces a toxic molecule upon activation by light and (b) a photosensitive molecule that does not become toxic or produce a toxic molecule upon activation by light. 7. The method of claim 6 , wherein the subject has a bladder tumor. 8. The method of claim 6 , wherein the papilloma virus capsid proteins are non-human papilloma virus capsid proteins. 9. The method of claim 8 , wherein the non-human papilloma virus capsid proteins comprise L1 capsid proteins. 10. The method of claim 9 , wherein the non-human papilloma virus capsid proteins consist of L1 capsid proteins. 11. The method of claim 6 , wherein the photosensitive molecules are covalently conjugated to the capsid proteins. 12. The method of claim 6 , further comprising activating the photosensitive molecule of (b) at a wavelength of light that permits visualization of the photosensitive molecule of (b). 13. The method of claim 6 , further comprising activating the photosensitive molecule of (a) at a wavelength of light that causes the photosensitive molecule of (a) to become toxic or produce a toxic molecule. 14. The method of claim 6 , wherein the virus-like particle is delivered by injection.
Assignees
Inventors
Classifications
- A61K39/12Primary
Viral antigens · CPC title
specific for metastasis · CPC title
Virus like particles [VLP] · CPC title
Other apparatus for introducing media into the body (for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30); Percutany, i.e. introducing medicines into the body by diffusion through the skin (salt baths A61H33/04) · CPC title
Immunostimulants · CPC title
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Frequently asked questions
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- What does patent US11110181B2 cover?
- The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
- Who is the assignee on this patent?
- Aura Biosciences Inc, Us Health
- What technology area does this patent fall under?
- Primary CPC classification A61K39/12. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Sep 07 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).