Virus-like particle conjugates for diagnosis and treatment of tumors
US-2016228568-A1 · Aug 11, 2016 · US
HPV particles and uses thereof
US10179168B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10179168-B2 |
| Application number | US-201715636112-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 28, 2017 |
| Priority date | Apr 13, 2009 |
| Publication date | Jan 15, 2019 |
| Grant date | Jan 15, 2019 |
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- Title
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- Abstract
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Abstract
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The invention relates to modified HPV particles that can be used therapeutically. Modified HPV particles may be used to deliver therapeutic agents, including siRNA molecules. Modified HPV particles may be used for the treatment of diseases or conditions of mucosal tissue, including HPV (human papilloma virus) infection and HPV-related tumors.
First claim
Opening claim text (preview).
What is claimed is: 1. A nanoparticle comprising: a papillomavirus L1 protein comprising an FG loop corresponding to the amino acid sequence of SEQ ID NO: 66, wherein the papillomavirus L1 protein has reduced immunogenicity relative to wild-type human papillomavirus (HPV) serotype 16. 2. The nanoparticle of claim 1 , wherein the nanoparticle comprises at least one heterologous compound. 3. The nanoparticle of claim 2 , wherein the at least one heterologous compound comprises at least one therapeutic agent. 4. The nanoparticle of claim 2 , wherein the at least one heterologous compound comprises at least one diagnostic agent. 5. The nanoparticle of claim 1 , wherein the nanoparticle is a self-assembled nanoparticle. 6. The nanoparticle of claim 1 further comprising papillomavirus L2 capsid protein. 7. A method of delivering to a subject the nanoparticle of claim 1 . 8. The method of claim 7 , wherein the nanoparticle comprises at least one heterologous compound. 9. The method of claim 8 , wherein the at least one heterologous compound comprises at least one therapeutic agent. 10. The method of claim 8 , wherein the at least one heterologous compound comprises at least one diagnostic agent. 11. The method of claim 7 , wherein the nanoparticle is a self-assembled nanoparticle. 12. A papillomavirus L1 protein comprising an FG loop corresponding to the amino acid sequence of SEQ ID NO: 66, wherein the papillomavirus L1 protein has reduced immunogenicity relative to wild-type human papillomavirus (HPV) serotype 16.
Assignees
Inventors
Classifications
Reproductive system [uterus, ovaries, cervix, testes] · CPC title
Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors · CPC title
Antivirals · CPC title
Immunomodulators · CPC title
for herpes viruses · CPC title
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Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10179168B2 cover?
- The invention relates to modified HPV particles that can be used therapeutically. Modified HPV particles may be used to deliver therapeutic agents, including siRNA molecules. Modified HPV particles may be used for the treatment of diseases or conditions of mucosal tissue, including HPV (human papilloma virus) infection and HPV-related tumors.
- Who is the assignee on this patent?
- Inst Nat Sante Rech Med, Aura Biosciences Inc, Inst Nat Sante Rech Med
- What technology area does this patent fall under?
- Primary CPC classification A61K39/12. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 15 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).