Modulators of toll-like receptors

Patent metadata

Field	Value
Publication number	US-11110091-B2
Application number	US-201816201221-A
Country	US
Kind code	B2
Filing date	Nov 27, 2018
Priority date	Dec 9, 2008
Publication date	Sep 7, 2021
Grant date	Sep 7, 2021

Abstract

Provided are modulators of TLRs of Formula II:

pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.

First claim

We claim:

1. A compound of Formula II:

or a pharmaceutically acceptable salt thereof, wherein:
Y—Z is —CR 4 R 5 —CR 4 R 5 ;
L 1 is —NH— or —O—;
R 1 is C 1 -C 6 alkyl C 3 -C 12 saturated carbocyclyl, C 4 -C 20 saturated carbocyclylalkyl, or C 6 -C 20 arylalkyl;
X 1 is —CH 2 ;
D is phenyl substituted with -L 2 -NR 6 R 7 ;
each L 2 is independently C 1 -C 6 alkylene;
each R 3 is independently halogen, cyano, or C 1 -C 6 haloalkyl;
n is 0 or 1;
R 4 and R 5 are each H;
R 6 and R 7 are each independently H, C 1 -C 6 alkyl, or C 4 -C 20 saturated carbocyclylalkyl, —C(O)R 8 , —S(O)R 8 , —S(O) 2 R 8 , or —C(O)OR 8 ; or
R 6 and R 7 , taken together with the nitrogen to which they are both attached, form a 4-6 membered saturated heterocycle comprising 0 to 2 heteroatoms selected from N, O, or S; and
R 8 is H or C 1 -C 6 alkyl.

2. The compound of claim 1 selected from the group consisting of

or a pharmaceutically acceptable salt thereof.

3. A compound of formula:

or a pharmaceutically acceptable salt thereof.

Assignees

• Gilead Sciences Inc

Inventors

• Desai Manoj C
• Halcomb Randall L
• Hrvatin Paul
• Hui Hon Chung
• Mcfadden Ryan
• Roethle Paul A
• Yang Hong

Classifications

• Y02A50/30

  Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change · CPC title

• A61P11/00

  Drugs for disorders of the respiratory system · CPC title

• A61P1/04

  for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants · CPC title

• A61K31/683

  Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols · CPC title

• A61K38/21

  Interferons {[IFN]} · CPC title