Compounds for optically active devices

Patent metadata

Field	Value
Publication number	US-11078177-B2
Application number	US-201916560265-A
Country	US
Kind code	B2
Filing date	Sep 4, 2019
Priority date	Aug 21, 2015
Publication date	Aug 3, 2021
Grant date	Aug 3, 2021

Abstract

The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for ophthalmic devices as well as to ophthalmic devices comprising such compounds.

First claim

The invention claimed is:

1. An optically active intraocular lens article which comprises, a copolymer comprising: one or more polymer units M 1 selected from units of the following formulae (P-1) to (P-63); and one or more different polymer units:

wherein,
each * in the formulae indicates a linkage to an adjacent unit of the copolymer, and
n indicates the number of units of the formula.

2. The intraocular lens article according to claim 1 , wherein the one or more different polymer units in the copolymer comprise at least one unit M 2 , which at each occurrence is independently selected from the group consisting of a polymerized unit derived from ethylene, propylene, an acrylate, a methacrylate and a styrene.

3. The intraocular lens article according to claim 2 , wherein the copolymer comprises units M 1 and M 2 in a ratio m 1 :m 2 of from 0.01 to 100.

4. The intraocular lens article according to claim 1 , wherein intraocular lens article further comprises a UV absorber.

5. A process of forming the intraocular lens article of claim 1 , said process comprising:
a) providing a composition comprising the copolymer; and
b) subsequently forming the intraocular lens article from said composition.

6. A process of changing the optical properties of an intraocular lens article of claim 1 , said process comprising:
a) providing the intraocular lens article, and
b) subsequently exposing said article to irradiation having a wavelength of at least 200 nm and at most 1500 nm, whereby at least one optical property of the article is changed.

7. An intraocular lens article produced by the process according to claim 6 .

8. The intraocular lens article according to claim 1 , wherein one or more polymer units M 1 and/or one or more different polymer units in the copolymer are crosslinked with each other.

9. The intraocular lens article according to claim 1 , wherein the lens article further comprises one or more optic components and one or more haptic components, wherein the one or more optic components serve as a lens and the one or more haptic components are attached to the one or more optic components and hold the one or more optic components in place in the eye.

10. The intraocular lens article according to claim 9 , wherein the lens article has a one-piece design wherein the one or more optic components and the one or more haptic components are formed from a single piece of material.

11. The intraocular lens article according to claim 9 , wherein the lens article has a multi-piece design wherein the one or more optic components and the one or more haptic components are formed separately and then combined.

12. A process of forming the intraocular lens article of claim 1 , said process comprising:
a) polymerizing a compound according to formulae (M-1) to (M-63) together with precursor materials to produce the copolymer having one or more polymer units M 1 and the one or more different polymer units

b) subsequently forming the intraocular lens article from said composition.

Assignees

• Merck Patent Gmbh

Inventors

• Dobelmann-Mara Lars
• Riedmueller Stefan
• Schraub Martin

Classifications

• C07D335/06

  Benzothiopyrans; Hydrogenated benzothiopyrans · CPC title

• C08F20/30

  containing aromatic rings in the alcohol moiety · CPC title

• C08F20/38

  Esters containing sulfur · CPC title

• C07D311/16 Primary

  substituted in position 7 · CPC title

• A61L27/16

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title