Micro device for solid phase extraction

Patent metadata

Field	Value
Publication number	US-11065557-B2
Application number	US-201816631341-A
Country	US
Kind code	B2
Filing date	Oct 12, 2018
Priority date	Nov 17, 2017
Publication date	Jul 20, 2021
Grant date	Jul 20, 2021

Abstract

The present invention relates to a micro device for solid phase extraction and more particularly provides a micro device which is configured to perform solid phase extraction by injecting a filler and a solvent and producing a uniform flow of the solvent.

First claim

What is claimed is:

1. A micro device for solid phase extraction comprising:
an inlet configured to receive injection of a solvent and a filler;
an outlet configured to receive discharging of the solvent; and
a dam-forming portion located between the inlet and the outlet, the dam-forming portion having a first end portion adjacent to the inlet and a protruded portion adjacent to the outlet, the protruded portion having a diameter greater than a diameter of the first end portion, the protruded portion having a circular, cylindrical, or conical cross section; and
a dam disposed within the protruded portion of the dam-forming portion, the dam configured to allow the solvent to flow therethrough but configured to prevent the filler from passing therethrough,
wherein each of the dam-forming portion and the dam has a circular cross section with respect to a central axis of the micro device, the central axis extending in a longitudinal direction of the inlet in which the inlet extends, each cross section being perpendicular to the central axis, and wherein the dam-forming portion is configured to accommodate the filler thereon, the filler configured to be deposited onto the dam in the form of a disk that is centered with respect to the central axis in the dam-forming portion, the filler having a minimum diameter, and
wherein a gap is defined between an outer peripheral edge of a top surface of the dam and a transition edge at which the first end portion meets the protruded portion, the gap being less than or equal to the minimum diameter of the filler.

2. The micro device according to claim 1 , wherein each of the inlet and the outlet has a circular cross section with respect to the central axis, the cross section of each of the inlet and the outlet being perpendicular to the central axis, and
wherein a diameter of the inlet and a diameter of the outlet are each smaller than a diameter of the dam-forming portion.

3. The micro device according to claim 1 , wherein the dam-forming portion has a first end portion connected to the inlet and a second end portion connected to the outlet, the first and second end portions being at opposite ends of the dam-forming portion, and wherein the dam is located closer to the second end portion than the first end portion, and the dam is spaced apart from the second end portion by a predetermined distance.

4. The micro device according to claim 3 , wherein each of the second end portion and a portion of the dam facing the second end portion has a respective surface protruding toward the outlet.

5. The micro device according to claim 4 , wherein the surface of the second end portion and the surface of the portion of the dam each have a conical shape.

6. The micro device according to claim 1 , wherein the filler is in the form of beads.

7. The micro device according to claim 1 , wherein a total diameter of the micro device in a plane perpendicular to the longitudinal direction is 25 mm to 32 mm and a total length of the micro device in the longitudinal direction is 10 mm.

8. The micro device according to claim 7 , wherein a diameter of particles of the filler is from 35 μm to 60 μm,
a diameter of the inlet is 0.5 mm to 10 mm and a length of the inlet is 5 mm,
a diameter of the outlet is 0.5 mm to 10 mm and a length of the outlet is 5 mm,
a distance from a first end portion of the dam-forming portion to a surface of the dam facing the first end portion is 0.2 mm to 0.3 mm,
a distance from the surface of the dam facing the first end portion to a second end portion of the dam-forming portion is 100 μm to 150 μm, and
a thickness of the dam in the longitudinal direction is 30 μm to 35 μm.

Assignees

• Lg Chemical Ltd

Inventors

• Jegal Seonyoung
• Kim Dae Hun
• Kim Byoung Hyoun
• Youn Yeu Young
• Jin Kyoungjoo
• Choi Jun Won
• Han Su Youn

Classifications

• B01D11/02 Primary

  of solids · CPC title

• B01L3/502753 Primary

  characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation · CPC title

• G01N2030/009

  Extraction · CPC title

• G01N1/405

  by adsorption or absorption · CPC title

• B01D11/0219

  Fixed bed of solid material · CPC title