Oral care compositions

Patent metadata

Field	Value
Publication number	US-11065186-B2
Application number	US-201916267424-A
Country	US
Kind code	B2
Filing date	Feb 5, 2019
Priority date	Dec 30, 2015
Publication date	Jul 20, 2021
Grant date	Jul 20, 2021

Abstract

Provided are aqueous soluble tin phosphate complexes formed from a mixture comprising tin (II) fluoride or tin (II) chloride and a tripolyphosphate salt, e.g., sodium tripolyphosphate (Na 5 P 3 O 10 ), and oral care compositions comprising the complex and uses thereof.

First claim

What is claimed is:

1. An oral care composition comprising an aqueous soluble tin phosphate complex formed from a mixture comprising tin (II) fluoride or tin (II) chloride and a tripolyphosphate salt;
wherein the complex is formed in situ in an aqueous solution and combined with the composition;
or is isolated from the aqueous solution in solid form and combined with the composition;
or is lyophilized and combined with the composition;
or is isolated with an anti-solvent and combined with the composition,
and the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of 2P:1Sn to 10P:1Sn, and
wherein the complex is present in an amount of 2 to 30 weight % by weight of the composition,
wherein the composition is in the form of a mouthwash, oral gel, or dentifrice.

2. The composition of claim 1 , wherein the tripolyphosphate salt is sodium tripolyphosphate (Na 5 P 3 O 10 ).

3. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of 2P:1Sn to 5P:1Sn.

4. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of 3P:1Sn to 5P:1Sn.

5. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of 5P:1Sn.

6. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and sodium tripolyphosphate in a molar ratio of 2P:1Sn to 5P:1Sn.

7. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and sodium tripolyphosphate in a molar ratio of 3P:1Sn to 5P:1Sn.

8. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and sodium tripolyphosphate in a molar ratio of 5P:1Sn.

9. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride or tin (II) chloride by weight of the mixture and 1 to 20 weight % tripolyphosphate salt by weight of the mixture.

10. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride or tin (II) chloride by weight of the mixture and 1 to 10 weight % tripolyphosphate salt by weight of the mixture.

11. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride or tin (II) chloride by weight of the mixture and 1 to 20 weight % sodium tripolyphosphate by weight of the mixture.

12. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride or tin (II) chloride by weight of the mixture and 1 to 10 weight % sodium tripolyphosphate by weight of the mixture.

13. The composition of claim 1 , wherein the composition comprises tin (II) fluoride.

14. The composition of claim 1 , wherein the composition comprises tin (II) chloride.

15. The composition of claim 1 , wherein the composition comprises an aqueous solution.

16. The composition of claim 1 further comprising more than 20 weight % water by weight of the composition.

17. The composition of claim 1 , wherein the composition is a mouthwash.

18. The composition of claim 1 for use to reduce dentinal hypersensitivity.

19. A method to reduce or inhibit dentinal hypersensitivity, dental caries, gingivitis, or plaque in a person in need thereof comprising applying an effective amount of an oral care composition as claimed in claim 1 to teeth of the person.

20. The composition of claim 1 , wherein the complex forms a precipitate with salivary proteins.

Assignees

• Colgate Palmolive Co

Inventors

• Nawrocki Shiri
• Dubovoy Viktor
• Pan Long
• Hao Zhigang
• Dogu Nihal

Classifications

• A61K8/19

  containing inorganic ingredients · CPC title

• A61K8/24 Primary

  Phosphorous; Compounds thereof · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title