Ultra-low field nuclear magnetic resonance device

Patent metadata

Field	Value
Publication number	US-11064900-B2
Application number	US-201716085488-A
Country	US
Kind code	B2
Filing date	Apr 3, 2017
Priority date	Apr 4, 2016
Publication date	Jul 20, 2021
Grant date	Jul 20, 2021

Abstract

Provided are an ultra-low field nuclear magnetic resonance device and a method for measuring an ultra-low field nuclear resonance image. The ultra-low field nuclear magnetic resonance device includes an AC power supply configured to supply a current to a measurement target in such a manner the current flows to the measurement target, magnetic field measurement means disposed adjacent to the measurement target, and measurement bias magnetic field generation means configured to apply a measurement bias magnetic field corresponding to a proton magnetic resonance frequency of the measurement target. A vibration frequency of the AC power supply matches the proton magnetic resonance frequency of the measurement target, and the magnetic field measurement means measures a nuclear magnetic resonance signal generated from the measurement target.

First claim

What is claimed is:

1. An ultra-low field nuclear magnetic resonance device comprising:
an AC power supply configured to supply a current to a measurement target in a manner so that the current flows in the measurement target, the measurement target having a proton magnetic resonance frequency;
a magnetic field measurement part adjacent to the measurement target; and
a measurement bias magnetic field generator configured to apply a measurement bias magnetic field corresponding to the proton magnetic resonance frequency of the measurement target,
wherein:
the AC power supply has a first vibration frequency that matches the proton magnetic resonance frequency of the measurement target,
the current in the measurement target produces a modulated magnetic field, and
the magnetic field measurement part is configured to measure a nuclear magnetic resonance signal from the measurement target.

2. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , further comprising:
a pre-polarizing magnetic field generator configured to produce a pre-polarizing magnetic field in a first direction and apply the pre-polarizing magnetic field for an application time to pre-polarize the measurement target,
wherein:
the measurement bias magnetic field has a second direction, and the first direction matches the second direction, and
after the application time, the measurement bias magnetic field generator applies the measurement bias magnetic field, and the current in the modulation target produces the modulated magnetic field.

3. The ultra-low field nuclear magnetic resonance device as set forth in claim 2 , wherein the pre-polarizing magnetic field generator comprises a resistive coil, a superconducting coil, a pancake-type coil or a solenoid coil.

4. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , further comprising:
a pre-polarizing magnetic field generator configured to produce a pre-polarizing magnetic field to pre-polarize the measurement target; and
an excitation magnetic field generator configured to switch a magnetization direction of the measurement target,
wherein:
the measurement bias magnetic field has a first direction, and the pre-polarizing magnetic field has a second direction that is perpendicular to the first direction, and
the excitation magnetic field generator rotates the magnetization direction in the first direction.

5. The ultra-low field nuclear magnetic resonance device as set forth in claim 4 , wherein:
the excitation magnetic field generator is configured to generate a circularly polarized excitation magnetic field.

6. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , further comprising:
a pre-polarizing magnetic field generator configured to apply a pre-polarizing magnetic field to pre-polarize the measurement target,
wherein:
the measurement bias magnetic field has a first direction, and the pre-polarizing magnetic field generator is configured to produce the pre-polarizing magnetic field in a second direction perpendicular to the first direction,
the pre-polarizing magnetic field has a magnitude,
the measurement target has a magnetization direction, and
When the measurement bias magnetic field generator applies the measurement bias magnetic field, the pre-polarizing magnetic field generator is configured to adiabatically reduce the magnitude of the pre-polarizing magnetic field so that the magnetization direction of the measurement target is aligned in the first direction.

7. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , further comprising:
a gradient magnetic field generator configured to provide a gradient magnetic field to the measurement target.

8. The ultra-low field nuclear magnetic resonance device as set forth in claim 7 , wherein the gradient magnetic field generator comprises a triaxial gradient magnetic field coil.

9. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , wherein the measurement target is a part of a human body.

10. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , wherein the measurement target is an organ in a human body.

11. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , wherein the current is an alternating current that flows to the measurement target by an electrode pad, the alternating current in the measurement target generates the modulated magnetic field, and the modulated magnetic field has a predetermined vibration frequency.

12. The ultra-low field nuclear magnetic resonance device as set forth in claim 11 , configured to apply the modulated magnetic field to the measurement target as a pulse for an application time of 30-150 ms.

13. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , wherein the magnetic field measurement part comprises a superconducting quantum interference device.

14. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , wherein the measurement bias magnetic field generator comprises a double Helmholtz coil.

15. The ultra-low field nuclear magnetic resonance device as set forth in claim 1 , wherein the modulated magnetic field has a second vibration frequency identical to the proton magnetic resonance frequency of the measurement target.

16. A method for measuring an ultra-low field nuclear resonance image comprising:
applying a pre-polarizing magnetic field to pre-polarize a measurement target, the measurement target having a proton magnetic resonance frequency;
applying a measurement bias magnetic field corresponding to the proton magnetic resonance frequency, the measurement bias magnetic field having a first vibration frequency;
producing a modulated magnetic field in the measurement target by providing an alternating current to the measurement target, the alternating current having a second vibration frequency corresponding to the proton magnetic resonance frequency;
applying a gradient magnetic field to the measurement target;
generating a nuclear magnetic resonance signal from the measurement target;
measuring the nuclear magnetic resonance; and
obtaining a current image of the measurement target using the nuclear magnetic resonance signal,
wherein:
the second vibration frequency corresponds to the first vibration frequency.

17. The method as set forth in claim 16 , wherein:
the pre-polarizing, magnetic field has a first direction, the measurement bias magnetic field has a second direction, and applying the pre-polarizing magnetic field further comprises matching the first direction to the second direction, and
the modulated magnetic field has a third direction, and the third direction is perpendicular to the second direction.

18. The method as set firth in claim 16 , wherein the measurement target has a magnetization direction, the measurement bias magnetic field has a first direction, and the method further comprises:
providing an excitation magnetic field to switch the magnetization direction of the measurement target to the first direction,
wherein:
the pre-polarizing magnetic field has a second direction, the pre-polarizing magnetic field aligns the magnetization direction of the measurement target in the second direction, and the second direction is perpendicular to the first direction, and
when providing the excitation magnetic field, the excitation magnetic field rotates the magnetization direction of the measurement target from the second direction to the firs

Assignees

• Korea Res Inst Standards & Sci

Inventors

• Lee Seong-Joo
• Kim Kiwoong
• Shim Jeong-Hyun
• Yu Kwon-Kyu
• Hwang Seong-Min

Classifications

• A61B5/055 Primary

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G01R33/326

  involving a SQUID · CPC title

• G01R33/421

  of main or gradient magnetic field · CPC title

• G01R33/381

  using electromagnets · CPC title

• G01R33/56

  Image enhancement or correction, e.g. subtraction or averaging techniques {, e.g. improvement of signal-to-noise ratio and resolution} · CPC title