Ultra-low-field nuclear-magnetic-resonance direct myocardial electrical activity detection method and ultra-low-field nuclear-magnetic-resonance device

Patent metadata

Field	Value
Publication number	US-10028674-B2
Application number	US-201313891533-A
Country	US
Kind code	B2
Filing date	May 10, 2013
Priority date	Nov 23, 2010
Publication date	Jul 24, 2018
Grant date	Jul 24, 2018

Abstract

Provided are ultra-low-field nuclear-magnetic-resonance myocardial electrical activity detection method and an ultra-low-field nuclear-magnetic-resonance device. The ultra-low-field nuclear-magnetic-resonance device includes magnetic shielding room; a high-sensitivity magnetic field sensor disposed adjacent to a measurement target disposed inside the magnetic shielding room; and a bias magnetic field generating coil for providing an external measurement bias magnetic field, corresponding to a proton magnetic resonance frequency (nuclear magnetic resonance frequency) corresponding to a frequency of periodic myocardial activity of a lesion desired to be measured, to the measurement target. The high-sensitivity magnetic field sensor measures a magnetic resonance signal generated from the measurement target.

First claim

What is claimed is:

1. An ultra-low-field nuclear-magnetic-resonance device comprising:
a magnetic shielding room configured for reducing Earth's magnetic field;
a high-sensitivity magnetic field sensor disposed adjacent to a measurement target disposed inside the magnetic shielding room; and
a bias magnetic field generating coil disposed inside the magnetic shielding room, the bias magnetic field generating coil being configured for providing an external measurement bias magnetic field to the measurement target, the external measurement bias magnetic field corresponding to a proton magnetic resonance frequency (nuclear magnetic resonance frequency) corresponding to a frequency of periodic myocardial activity of a lesion desired to be measured,
wherein the high-sensitivity magnetic field sensor measures a magnetic resonance signal generated from the measurement target;
wherein the bias magnetic field generating coil scans the external measurement magnetic field according to a frequency of a signal desired to be measured; and
wherein an orientation of the external measurement bias magnetic field and a pre-polarization magnetic field is switched.

2. The ultra-low-field nuclear-magnetic-resonance device of claim 1 , further comprising:
a pre-polarization coil configured for generating the pre-polarization magnetic field by pre-polarizing the measurement target;
wherein the pre-polarization coil is disposed inside the magnetic shielding room.

3. The ultra-low-field nuclear-magnetic-resonance device of claim 1 , further comprising:
a gradient magnetic field generating coil configured for providing a gradient magnetic field to the measurement target;
wherein the gradient magnetic field generating coil is disposed inside the magnetic shielding room.

Assignees

• Korea Res Inst Standards & Sci

Inventors

• Kim Kiwoong
• Lee Yong-Ho
• Kim Jin-Mok
• Kwon Hyukchan
• Yu Kwon Kyu

Classifications

• A61B5/0044

  for the heart · CPC title

• G01R33/445

  MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging · CPC title

• G01R33/24

  for measuring direction or magnitude of magnetic fields or magnetic flux · CPC title

• A61B5/055 Primary

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title