Natural product formulations with improved residual insect repellent/deterrent activity

Patent metadata

Field	Value
Publication number	US-11064704-B2
Application number	US-201716343567-A
Country	US
Kind code	B2
Filing date	Oct 20, 2017
Priority date	Oct 21, 2016
Publication date	Jul 20, 2021
Grant date	Jul 20, 2021

Abstract

Natural products were screened for their insect repellent activity, and carrot seed essential oil gave very high activity in biting repellent/deterrent bioassays. Analysis of the oil revealed the presence of 47 compounds, mainly mono- and sesqui-terpenes. The sesquiterpene, carotol, constituted more than 75% w/w of the oil. In the initial screening, the essential oil gave high biting deterrent activity and high repellent activity comparable to DEET against both Aedes aegypti and Anophies quadrimaculatus species of mosquitoes. The active fraction mainly comprises pure carotol. The essential oil and the pure compound have a potential to be developed and used as effective repellent against mosquitoes.

First claim

The invention claimed is:

1. A mosquito repellent/deterrent comprising a mosquito repellant/deterrent amount of at least one of carrot seed essential oil or carotol and mixtures thereof further comprising DEET said deterrent being either alone or in an acceptable carrier therefor, wherein, in the case of mosquitoes that are vectors of disease causing pathogenic microbes, the repellent/deterrent is additionally effective for preventing infection with such diseases.

2. The mosquito repellent/deterrent according to claim 1 , further comprising undecanoic acid.

3. A method for protecting individuals from mosquito bites comprising applying to an individual a mosquito repellent/deterrent according to claim 1 .

4. The method for protecting individuals from mosquito bites comprising applying to an individual a mosquito repellent/deterrent according to claim 2 .

5. An insect repellent/deterrent comprising an insect repellant/deterrent amount of at least one of carrot seed essential oil or carotol and mixtures thereof and DEET, the repellent/deterrent being either alone or in an acceptable carrier therefor.

6. The insect repellant/deterrent according to claim 5 , further comprising undecanoic acid.

Assignees

• Univ Mississippi

Inventors

• Ali Abbas
• Khan Ikhlas A
• Radwan Mohamed Mahmoud

Classifications

• Y02A50/30

  Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change · CPC title

• A01N37/06

  Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof · CPC title

• A01N35/04

  containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals · CPC title

• A01N31/06

  Oxygen or sulfur directly attached to a cycloaliphatic ring system · CPC title

• A01N37/18

  containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof · CPC title