External wound-healing agent, and external wound-healing material

Patent metadata

Field	Value
Publication number	US-11058660-B2
Application number	US-201816236752-A
Country	US
Kind code	B2
Filing date	Dec 31, 2018
Priority date	Jul 15, 2014
Publication date	Jul 13, 2021
Grant date	Jul 13, 2021

Abstract

A method of healing an external wound involves applying an external wound-healing agent to an external wound, or bringing the external wound-healing agent applied to a substrate into contact with an external wound, wherein the external wound-healing agent includes, as an active ingredient, at least one compound of a glycerol alkyl ester represented by defined Formula (I) or a diglycerol alkyl ester represented by defined Formula (II). In a further embodiment, the method involves bringing a fiber aggregate or a film into contact with an external wound, wherein the fiber aggregate or the film each includes a thermoplastic resin and at least one compound of the glycerol alkyl ester or the diglycerol alkyl ester.

First claim

The invention claimed is:

1. A method of healing an external wound, the method comprising:
applying an external wound-healing agent to an external wound, or bringing the external wound-healing agent applied to a substrate into contact with an external wound, or bringing a fiber aggregate or a film into contact with an external wound,
wherein the external wound-healing agent comprises an active ingredient consisting of a glycerol alkyl ester, or the fiber aggregate or the film each comprises: a thermoplastic resin; and an active ingredient, consisting of the glycerol alkyl ester, wherein the glycerol alkyl ester is represented by the following Formula (I):

and
wherein, in Formula (I), one of R 1 , R 2 , and R 3 is C 17 H 35 CO— or C 19 H 39 CO—, and the others are a hydrogen atom wherein the method does not comprise administration of any additional active ingredients; and.

2. The method of healing an external wound according to claim 1 , wherein the glycerol alkyl ester is glycerol stearate.

3. The method of healing an external wound according to claim 1 , wherein the amount of the glycerol alkyl ester represented by the Formula (I) is from 0.05 part by mass to 5 parts by mass with respect to 100 parts by mass of the external wound-healing agent.

4. The method of healing an external wound according to claim 1 , wherein the thermoplastic resin is at least one resin selected from the group consisting of olefin resins, urethane resins, amide resins, ester resins, acrylic resins, styrene resins, and carbonate resins.

5. The method of healing an external wound according to claim 4 , wherein the thermoplastic resin is an olefin resin.

6. The method of healing an external wound according to claim 5 , wherein the olefin resin is at least one of an ethylene copolymer or a propylene copolymer.

7. The method of healing an external wound according to claim 1 , wherein the fiber aggregate is a nonwoven fabric.

8. The method of healing an external wound according to claim 1 , wherein the amount of the glycerol alkyl ester represented by the Formula (I) is from 0.05 part by mass to 5 parts by mass with respect to 100 parts by mass of the thermoplastic resin.

9. A method of healing an external wound, the method comprising:
applying an external wound-healing agent to an external wound, or bringing the external wound-healing agent applied to a substrate into contact with an external wound, or bringing a fiber aggregate or a film into contact with an external wound,
wherein the external wound-healing agent comprises, as an active ingredient, a glycerol alkyl ester, or the fiber aggregate or the film each comprises: a thermoplastic resin; and, as an active ingredient, the glycerol alkyl ester, wherein the glycerol alkyl ester is represented by Formula (I):

and
wherein in Formula (I), one of R 1 , R 2 , and R 3 is C 19 H 39 CO—, and the others are a hydrogen atom.

Assignees

• Mitsui Chemicals Inc

Inventors

• Kunimoto Naosuke
• Suzuki Kenichi
• Kojima Kouya
• Hasegawa Akira
• Tsuchiya Yasufumi
• Kamada Jun
• Yamasaki Satoshi
• Kuwamura Goro
• Hasegawa Daisuke

Classifications

• A61L2300/412

  Tissue-regenerating or healing or proliferative agents · CPC title

• A61K9/7007

  Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence) · CPC title

• A61K31/23 Primary

  of acids having a carboxyl group bound to a chain of seven or more carbon atoms · CPC title

• A61K9/70

  Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} · CPC title

• A61L15/44

  Medicaments · CPC title