Dissolution of oxidized cellulose and particle preparation by cross-linking with multivalent cations

Patent metadata

Field	Value
Publication number	US-11053323-B2
Application number	US-201615344633-A
Country	US
Kind code	B2
Filing date	Nov 7, 2016
Priority date	Jun 28, 2012
Publication date	Jul 6, 2021
Grant date	Jul 6, 2021

Abstract

A process for dissolving modified cellulose includes contacting modified cellulose solution with at least one multivalent cation to form a plurality of modified cellulose particles.

First claim

What is claimed is:

1. A process for forming a composition comprising:
forming an oxidized cellulose solution;
forming a cationic composition cross-linkable with the oxidized cellulose solution, the cationic composition including an aqueous solution of chitosan having a pH from about 2.0 to about 6.0; and
contacting the oxidized cellulose solution and the cationic composition at a tissue treatment site thereby forming an ionically cross-linked gel, by convergently applying the oxidized cellulose solution and the cationic composition onto the tissue treatment site.

2. The process according to claim 1 , wherein the formation of the oxidized cellulose solution comprises:
contacting an oxidized cellulose with a solvent under an inert atmosphere to form a swelled oxidized cellulose mixture;
adjusting the swelled oxidized cellulose mixture to a first temperature;
contacting the swelled oxidized cellulose mixture with a salt under the inert atmosphere to form an oxidized cellulose solution; and
adjusting the oxidized cellulose solution to a second temperature that is lower than the first temperature.

3. The process according to claim 1 , wherein the oxidized cellulose solution has a pH from about 8.0 to about 9.5.

4. A process for forming a composition comprising:
forming an oxidized cellulose solution;
forming a cationic composition cross-linkable with the oxidized cellulose solution, the cationic composition is an aqueous solution of at least one multivalent cation selected from the group consisting of cations of calcium, barium, zinc, magnesium, chromium, platinum, and iron; and
contacting the oxidized cellulose solution and the cationic composition at a tissue treatment site thereby forming an ionically cross-linked gel, by convergently applying the oxidized cellulose solution and the cationic composition onto the tissue treatment site.

5. The process according to claim 4 , wherein the formation of the oxidized cellulose solution comprises:
contacting an oxidized cellulose with a solvent under an inert atmosphere to form a swelled oxidized cellulose mixture;
adjusting the swelled oxidized cellulose mixture to a first temperature;
contacting the swelled oxidized cellulose mixture with a salt under the inert atmosphere to form an oxidized cellulose solution; and
adjusting the oxidized cellulose solution to a second temperature that is lower than the first temperature.

6. The process according to claim 4 , wherein the oxidized cellulose solution has a pH from about 8.0 to about 9.5.

Assignees

• Covidien Lp

Inventors

• Blaskovich Phillip
• Tramontano Valentino
• Ohri Rachit
• Kennedy Joshua
• Henry Christopher M

Classifications

• C08J3/096

  Nitrogen containing compounds · CPC title

• C08J3/14

  by precipitation from solutions {(C08J3/122 takes precedence)} · CPC title

• C08B1/003 Primary

  Preparation of cellulose solutions, i.e. dopes, with different possible solvents, e.g. ionic liquids (solutions used in the manufacture of monocomponent artificial filaments or cellulose or derivatives thereof D01F2/02) · CPC title

• C08L1/04

  Oxycellulose; Hydrocellulose {, e.g. microcrystalline cellulose} · CPC title

• C08J2301/04

  Oxycellulose; Hydrocellulose · CPC title