Multi-encapsulated microspheres made with oxidized cellulose for in-situ reactions

Patent metadata

Field	Value
Publication number	US-9168227-B2
Application number	US-201314024871-A
Country	US
Kind code	B2
Filing date	Sep 12, 2013
Priority date	May 31, 2012
Publication date	Oct 27, 2015
Grant date	Oct 27, 2015

Abstract

A microsphere and methods for forming the same are disclosed. The microsphere includes modified cellulose and at least one first microsphere disposed within a multi-encapsulating microsphere, the at least one first microsphere comprising at least one first hydrogel precursor; and at least one second microsphere disposed within the multi-encapsulating microsphere, the at least one second microsphere comprising at least one second hydrogel precursor cross-linkable with the at least one first hydrogel precursor upon degradation of the at least one first microsphere and the at least one second microsphere.

First claim

What is claimed is:

1. A multi-encapsulating microsphere comprising:
modified cellulose;
at least one first microsphere disposed within the multi-encapsulating microsphere, the at least one first microsphere comprising at least one first hydrogel precursor; and
at least one second microsphere disposed within the multi-encapsulating microsphere, the at least one second microsphere comprising at least one second hydrogel precursor cross-linkable with the at least one first hydrogel precursor upon degradation of the at least one first microsphere and the at least one second microsphere.

2. The multi-encapsulating microsphere according to claim 1 , wherein the at least one first hydrogel precursor comprises at least one electrophilic functional group.

3. The multi-encapsulating microsphere according to claim 2 , wherein the at least one electrophilic functional group is selected from the group consisting of N-hydroxysuccinimides, sulfosuccinimides, and combinations thereof.

4. The multi-encapsulating microsphere according to claim 1 , wherein the at least one second hydrogel precursor comprises at least one nucleophilic functional group.

5. The multi-encapsulating microsphere according to claim 4 , wherein the at least one nucleophilic functional group is selected from the group consisting of amines, thiols, and combinations thereof.

6. The multi-encapsulating microsphere according to claim 1 , further comprising:
at least one third microsphere disposed within the multi-encapsulating microsphere, the at least one third microsphere encapsulating the at least one second microsphere.

Assignees

• Confluent Surgical Inc
• Covidien Lp

Inventors

• Blaskovich Phillip D
• Herman Clifford J
• Nichols Gary A
• Ohri Rachit
• Pham Lan

Classifications

• A61K9/1647

  Polyesters, e.g. poly(lactide-co-glycolide) · CPC title

• A61K9/5084

  Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs (tablets containing such a mixture A61K9/2077) · CPC title

• A61K9/5073

  having two or more different coatings optionally including drug-containing subcoatings · CPC title

• A61K9/1652 Primary

  Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623) · CPC title

• A61K47/38

  Cellulose; Derivatives thereof · CPC title