Methods of treating fibrosis

Patent metadata

Field	Value
Publication number	US-11046641-B2
Application number	US-201715593864-A
Country	US
Kind code	B2
Filing date	May 12, 2017
Priority date	Feb 9, 2012
Publication date	Jun 29, 2021
Grant date	Jun 29, 2021

Abstract

The present disclosure is directed in part to methods of treating fibrosis, e.g., hepatic fibrosis and/or intestinal fibrosis, comprising administering to a patient in need thereof an effective amount of a disclosed compound.

First claim

We claim:

1. A method of treating idiopathic pulmonary fibrosis, the method comprising administering to a patient in need thereof, a therapeutically effective amount of 2-methoxy-3-(4′-aminophenyl)-propionic acid,
or a pharmaceutically acceptable salt and/or a stereoisomer thereof.

2. The method of claim 1 , wherein the 2-methoxy-3-(4′-aminophenyl)propionic acid is (S)-2-methoxy-3-(4′-aminophenyl)propionic acid, or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 , wherein the administering is orally.

4. The method of claim 1 , wherein the patient is human.

5. A method of treating idiopathic pulmonary fibrosis, the method comprising administering to a patient in need thereof, a pharmaceutical preparation comprising a therapeutically effective amount of 2-methoxy-3-(4′-aminophenyl)-propionic acid,
or a pharmaceutically acceptable salt and/or a stereoisomer thereof.

6. The method of claim 5 , wherein the pharmaceutical preparation is administered orally.

7. The method of claim 5 , wherein the patient is human.

8. The method of claim 5 , wherein the 2-methoxy-3-(4′-aminophenyl)propionic acid is (S)-2-methoxy-3-(4′-aminophenyl)propionic acid, or a pharmaceutically acceptable salt thereof.

Assignees

• Nogra Pharma Ltd

Inventors

• Baroni Sergio
• Bellinvia Salvatore
• Viti Francesca

Classifications

• A61K31/196 Primary

  the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil · CPC title

• A61P1/04

  for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants · CPC title

• A61K31/357

  having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel · CPC title

• A61K31/343

  condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone · CPC title

• C07C229/44 Primary

  with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by unsaturated carbon chains · CPC title