Esters of 2-deoxy-monosacharides with anti proliferative activity
US-10201554-B2 · Feb 12, 2019 · US
US11026960B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11026960-B2 |
| Application number | US-201816229338-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 21, 2018 |
| Priority date | Apr 5, 2013 |
| Publication date | Jun 8, 2021 |
| Grant date | Jun 8, 2021 |
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Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.
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What is claimed is: 1. A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of one or more compounds of the Formula I: or a salt thereof, wherein: each R 1 , R 2 , R 3 and R 4 are independently H, or C(O)R 5 ; at least two of R 1 , R 2 , R 3 and R 4 is C(O)R 5 ; and each R 5 is independently selected from C 3 -C 7 straight- or branched-chain alkyl, C 4 -C 10 alkylcycloalkyl, and C 3 -C 7 cycloalkyl. 2. The method of claim 1 , wherein R 2 and R 3 are C(O)R 5 . 3. The method of claim 1 , wherein the compound is chosen from: 4. A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of the compound 5. A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of the compound
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