Inhibitors of glycolysis useful in the treatment of brain tumors
US-9149489-B2 · Oct 6, 2015 · US
Esters of 2-deoxy-monosacharides with anti proliferative activity
US10201554B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10201554-B2 |
| Application number | US-201414782521-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 4, 2014 |
| Priority date | Apr 5, 2013 |
| Publication date | Feb 12, 2019 |
| Grant date | Feb 12, 2019 |
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- Title
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- Abstract
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Abstract
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Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.
First claim
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What is claimed is: 1. A method of treating brain cancer or pancreatic cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of one or more compounds of the Formula I: or a salt, ester or prodrug thereof, wherein: each R 1 , R 2 , R 3 and R 4 are independently H, or C(O)R 5 ; at least two of R 1 , R 2 , R 3 and R 4 is C(O)R 5 ; and each R 5 is independently selected from C 3 -C 7 straight- or branched-chain alkyl, C 4 -C 10 alkylcycloalkyl, and C 3 -C 7 cycloalkyl. 2. The method of claim 1 , wherein R 2 and R 3 are C(O)R 5 . 3. The method of claim 1 , wherein the compound is chosen from: or a salt thereof. 4. The method of claim 1 , wherein the cancer treated is pancreatic cancer. 5. The method of claim 1 , wherein the cancer treated is brain cancer. 6. The method of claim 5 , wherein the brain cancer is selected from the group consisting of glioblastoma, high-grade glioma, and metastatic brain cancer. 7. A method of treating brain cancer or pancreatic cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of the compound or a salt thereof. 8. A method of treating brain cancer or pancreatic cancer in a patient in need thereof comprising administering to the patient a therapeutically effective amount of the compound or a salt thereof.
Assignees
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Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
specific for metastasis · CPC title
specific for leukemia · CPC title
Antineoplastic agents · CPC title
- A61K31/7024Primary
Esters of saccharides · CPC title
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Frequently asked questions
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- What does patent US10201554B2 cover?
- Compounds and methods of using the same to inhibit glycolysis and treat cancer and other diseases are disclosed.
- Who is the assignee on this patent?
- Univ Texas, Conrad Kim
- What technology area does this patent fall under?
- Primary CPC classification A61K31/7024. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 12 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).