Raav with chemically modified capsid
US-2019388557-A1 · Dec 26, 2019 · US
Rod-shaped plant virus nanoparticles as imaging agent platforms
US11020497B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11020497-B2 |
| Application number | US-201816149828-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 2, 2018 |
| Priority date | Oct 9, 2012 |
| Publication date | Jun 1, 2021 |
| Grant date | Jun 1, 2021 |
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- Title
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Abstract
Official abstract text for this publication.
A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
First claim
Opening claim text (preview).
What is claimed is: 1. A spherical nanoparticle imaging platform, comprising a spherical arrangement of the coat proteins of one or more rod-shaped plant virus particles linked to an imaging agent on an interior surface of the virus particle, formed by thermal transition of the rod-shaped virus particles, wherein the imaging platform has a longitudinal relaxivity of greater than about 10 mM −1 S −1 per linked imaging agent when measured at 60 mHz at a physiological pH. 2. The spherical nanoparticle imaging platform of claim 1 , wherein the rod-shaped plant virus is a tobacco mosaic virus. 3. The spherical nanoparticle imaging platform of claim 1 , wherein the imaging agent is a chelated lanthanide. 4. The spherical nanoparticle imaging platform of claim 1 , wherein the imaging platform has a longitudinal relaxivity of greater than about 15 mM −1 S −1 per linked imaging agent when measured at 60 mHz at a physiological pH.
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Classifications
Nanotubes, nanorods or nanowires · CPC title
Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof (preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00) · CPC title
Uses of virus other than therapeutic or vaccine, e.g. disinfectant · CPC title
- A61K49/1896Primary
not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides · CPC title
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- What does patent US11020497B2 cover?
- A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region…
- Who is the assignee on this patent?
- Univ Case Western Reserve
- What technology area does this patent fall under?
- Primary CPC classification A61K49/1896. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jun 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).