Coated plant virus imaging agents
US-2016045624-A1 · Feb 18, 2016 · US
Coated plant virus imaging agents
US9925281B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9925281-B2 |
| Application number | US-201514818812-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 5, 2015 |
| Priority date | Aug 5, 2014 |
| Publication date | Mar 27, 2018 |
| Grant date | Mar 27, 2018 |
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Abstract
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An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed.
First claim
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What is claimed is: 1. An imaging nanoparticle, comprising a tobacco mosaic virus particle having an interior surface and an exterior surface, a gadolinium imaging agent that is linked to the interior surface, and a layer of silica over the exterior surface, wherein the virus has a relaxivity of greater than about 25,000 mM −1 S −1 per particle. 2. The imaging nanoparticle of claim 1 , wherein a targeting moiety is linked to the exterior surface of the virus particle. 3. The imaging nanoparticle of claim 2 , wherein the targeting moiety binds specifically to an immune cell. 4. The imaging nanoparticle of claim 1 , wherein at least about 500 imaging agent molecules are linked to the virus particle. 5. A method of generating an image of a tissue region of a subject, by administering to the subject a diagnostically effective amount of an imaging nanoparticle, comprising a tobacco mosaic virus particle having an interior surface and an exterior surface, gadolinium imaging agent that is linked to the interior surface, and a layer of silica over the exterior surface, and generating an image of the tissue region of the subject to which the imaging nanoparticle has been distributed, wherein the virus has a relaxivity of greater than about 25,000 mM −1 S −1 per particle. 6. The method of claim 5 , wherein the method of generating an image is magnetic resonance imaging. 7. The method of claim 5 , wherein the imaging nanoparticle further comprises a targeting moiety is linked to the exterior surface of the virus particle. 8. The method of claim 7 , wherein the targeting moiety specifically binds to an immune cell. 9. The method of claim 5 , wherein the tissue region includes a blood vessel.
Assignees
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Classifications
- A61K49/1896Primary
not provided for elsewhere, e.g. cells, viruses, ghosts, red blood cells, virus capsides · CPC title
the metal complex being Gd-DOTA · CPC title
conjugated systems · CPC title
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- What does patent US9925281B2 cover?
- An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer of biocompatible mineral such as silica coated over the exterior surface, is described. The imaging nanoparticle can be used in method of generating an image of a tissue region of a subject, by administ…
- Who is the assignee on this patent?
- Univ Case Western Reserve
- What technology area does this patent fall under?
- Primary CPC classification A61K49/1896. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 27 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).