Microchip substance delivery devices

Patent metadata

Field	Value
Publication number	US-11000474-B2
Application number	US-201715852943-A
Country	US
Kind code	B2
Filing date	Dec 22, 2017
Priority date	Sep 11, 2014
Publication date	May 11, 2021
Grant date	May 11, 2021

Abstract

Electromechanical substance delivery devices are provided which implement low-power electromechanical release mechanisms for controlled delivery of substances such as drugs and medication. For example, an electromechanical device includes a substrate having a cavity formed in a surface of the substrate, a membrane disposed on the surface of the substrate covering an opening of the cavity, and a seal disposed between the membrane and the surface of the substrate. The seal surrounds the opening of the cavity, and the seal and membrane are configured to enclose the cavity and retain a substance within the cavity. An electrode structure is configured to locally heat a portion of the membrane in response to a control voltage applied to the electrode structure, and create a stress that causes a rupture in the locally heated portion of the membrane to release the substance from within the cavity.

First claim

We claim:

1. An electromechanical device, comprising:
a substrate comprising a cavity formed in a surface of the substrate;
a membrane disposed over the surface of the substrate and covering an opening of the cavity, wherein the membrane comprises a stack of insulating layers comprising at least a first insulating layer and a second insulating layer;
a seal disposed between the membrane and the surface of the substrate, wherein the seal surrounds the opening of the cavity, and wherein the seal and the membrane are configured to enclose the cavity and retain a substance within the cavity; and
an electrode structure embedded within the stack of insulating layers of the membrane with the electrode structure disposed between the first and second insulating layers of the membrane;
wherein a surface area of a portion of the electrode structure that is disposed over the opening of the cavity is less than a surface area of the opening of the cavity; and
wherein the electrode structure is configured to locally heat a portion of the stack of insulating layers of the membrane in response to a control voltage applied to the electrode structure, and create a mechanical stress that causes a rupture in the locally heated portion of the stack of insulating layers of the membrane to release the substance from within the cavity.

2. The device of claim 1 , wherein the substance comprises medication.

3. The device of claim 1 , wherein the locally heated portion of the stack of insulating layers of the membrane has a lateral dimension that is less than about two times a thickness of the membrane.

4. The device of claim 1 , wherein a portion of the electrode structure comprises a V-shaped electrode, wherein an apex portion of the V-shaped electrode has a width that is less than a width of a remaining portion of the V-shaped electrode, and wherein the apex portion is configured to provide said localized heating of the locally heated portion of the stack of insulating layers of the membrane.

5. The device of claim 4 , wherein the V-shaped electrode is formed with an angle of about 108 degrees to about 120 degrees.

6. The device of claim 1 , further comprising a stress layer disposed on the membrane, wherein the stress layer is configured to apply a tensile stress to the membrane and cause a portion of the membrane to peel back away from a ruptured portion of the membrane.

7. The device of claim 1 , wherein the stack of insulating layers of the membrane comprises at least one silicon oxide layer and at least one silicon nitride layer.

8. The device of claim 1 , wherein the locally heated portion of the stack of insulating layers of the membrane further comprises a metallic material that is configured to melt due to said localized heating thereof.

9. An electromechanical device, comprising:
a substrate comprising a cavity formed in a surface of the substrate;
a seal disposed on the surface of the substrate surrounding an opening of the cavity;
a membrane disposed over the surface of the substrate and covering the opening of the cavity, wherein the membrane comprises a stack of insulating layers comprising at least a first insulating layer and a second insulating layer, and wherein the seal and the membrane are configured to enclose the cavity and retain a substance within the cavity;
an electrode structure embedded within the stack of insulating layers of the membrane with the electrode structure disposed between the first and second insulating layers of the membrane;
wherein the electrode structure comprises a first contact, a second contact, and a plurality of filaments arranged adjacent to each other, wherein the plurality of filaments are electrically connected in parallel to the first contact and the second contact of the electrode structure;
wherein a surface area of a portion of the electrode structure that is disposed over the opening of the cavity is less than a surface area of the opening of the cavity; and
wherein the filaments are configured to melt in succession in response to a control voltage applied to the first contact and the second contact, and cause a rupture in a portion of the stack of insulating layers of the membrane adjacent to the plurality of filaments to release the substance from within the cavity.

10. The device of claim 9 , wherein the plurality of filaments include parallel filaments disposed between the first and second contacts, wherein each filament of the plurality of filaments includes a fuse portion that is configured to melt, wherein a centrally disposed filament of the plurality of filaments has a width that is greater than widths of other filaments of the plurality of filaments, and wherein the widths of the other filaments of the plurality of filaments, which are disposed on each side of the centrally disposed filament, are successively smaller.

11. The device of claim 10 , wherein the fuse portions of the filaments of the plurality of filaments are arranged along a V-shaped line, wherein the fuse portion of the centrally disposed filament of the plurality of filaments is aligned to an apex of the V-shaped line.

12. An electromechanical device, comprising:
a substrate comprising a cavity formed in a surface of the substrate;
a membrane disposed over the surface of the substrate and covering an opening of the cavity, wherein the membrane comprises a stack of insulating layers comprising at least a first insulating layer and a second insulating layer, and a metallic membrane element disposed within an etched opening of at least the first insulating layer of the stack of insulting layers, wherein the metallic membrane element is aligned to the cavity;
a seal disposed between the membrane and the surface of the substrate, wherein the seal surrounds the opening of the cavity, and wherein the seal and the membrane are configured to enclose the cavity and retain a substance within the cavity; and
an electrode structure embedded within the stack of insulating layers of the membrane with the electrode structure disposed between the first and second insulating layers of the membrane and in contact with the metallic membrane element, wherein the electrode structure is configured to locally heat a portion of the metallic membrane element in response to a control voltage applied to the electrode structure, and cause at least one of melting and breaking of the locally heated portion of the metallic membrane element to release the substance from within the cavity.

13. An electromechanical device, comprising:
a substrate comprising a cavity formed in a surface of the substrate;
a membrane disposed over the surface of the substrate and covering an opening of the cavity;
a seal disposed between the membrane and the surface of the substrate, wherein the seal circumscribes the opening of the cavity, wherein the membrane is bonded to the seal, and wherein the seal and the membrane are configured to enclose the cavity and retain a substance within the cavity;
an electrode structure configured to locally heat a region in proximity to the seal in response to a control voltage applied to the electrode structure, and cause a mechanical stress that is effective to break at least a portion of the seal to release the substance from within the cavity, wherein the electrode structure is disposed on the substrate and surrounds at least a portion of a perimeter of the cavity formed in the substrate; and
a layer of polymer material disposed on the electrode structure, wherein the layer of polymer material comprises a volatile element, wherein the layer of polymer material is configured to release the volatile element in response to the heating of the polymer mate

Assignees

• IBM

Inventors

• Chey S Jay
• Dang Bing
• Knickerbocker John U
• Latzko Kenneth F
• Branquinho Teresa Maria Joana Sofia
• Turlapati Lavanya
• Webb Bucknell C
• Wright Steven L

Classifications

• A61N1/0428

  Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs · CPC title

• A61N1/0412

  Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs · CPC title

• A61N1/0448

  Drug reservoir · CPC title

• A61K9/0097 Primary

  Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon · CPC title

• A61M31/002

  Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time (artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50) · CPC title