Oral care compositions for promoting gum health

Patent metadata

Field	Value
Publication number	US-10980728-B2
Application number	US-202017026718-A
Country	US
Kind code	B2
Filing date	Sep 21, 2020
Priority date	Mar 29, 2018
Publication date	Apr 20, 2021
Grant date	Apr 20, 2021

Abstract

Oral care compositions comprising citrulline and stannous ion source with a specific pH range are provided for promoting Gum Health of a user.

First claim

What is claimed is:

1. An oral care composition comprising:
(a) stannous fluoride;
(b) stannous chloride; and
(c) citrulline in free or salt form,

wherein the oral care composition has a pH of 7.2 or less.

2. The oral care composition of claim 1 , wherein the composition has a pH of from 5.0 to 7.0.

3. The oral care composition of claim 2 , wherein the composition comprises from 0.01% to 15%, by weight of the composition, of citrulline.

4. The oral care composition of claim 1 , wherein the oral care composition comprises zinc.

5. The oral care composition of claim 4 , wherein the zinc comprises zinc citrate, zinc chloride, zinc sulfate, zinc gluconate, zinc lactate, zinc phosphate, zinc oxide, zinc carbonate, or combinations thereof.

6. The oral care composition of claim 1 , wherein the composition comprises from 0.01% to 5%, by weight of the composition, of a thickening agent selected from a thickening polymer, a thickening silica, or a combination thereof.

7. The oral care composition of claim 1 , wherein the composition comprises from 1% to 60%, by weight of the composition, of a humectant.

8. The oral care composition of claim 7 , wherein the humectant comprises glycerin, sorbitol, or combinations thereof.

9. The oral care composition of claim 1 , wherein the composition comprises abrasive.

10. The oral care composition of claim 9 , wherein the abrasive comprises silica abrasive, calcium-containing abrasive or combinations thereof.

11. The oral care composition of claim 10 , wherein the silica abrasive comprises precipitated silica.

12. The oral care composition of claim 10 , wherein the calcium-containing abrasive comprises calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcium orthophosphate, calcium metaphosphate, calcium polyphosphate, calcium oxyapatite, sodium carbonate, sodium bicarbonate, or combinations thereof.

13. An oral care composition comprising:
(a) anti-caries agent;
(b) stannous chloride; and
(c) citrulline in free or salt form,

wherein the oral care composition has a pH of 7.2 or less.

14. The oral care composition of claim 12 , wherein the anti-caries agent comprises stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, indium fluoride, amine fluoride, zinc fluoride, or combinations thereof.

15. The oral care composition of claim 14 , wherein the anti-caries agent is selected from the group consisting of sodium fluoride, sodium monofluorophosphate, amine fluoride, or combinations thereof.

16. The oral care composition of claim 14 , wherein the composition has a pH of from 5.0 to 7.0.

17. The oral care composition of claim 16 , wherein the composition comprises from 0.01% to 15%, by weight of the composition, of citrulline.

18. The oral care composition of claim 14 , wherein the oral care composition comprises zinc.

19. The oral care composition of claim 18 , wherein the zinc comprises zinc citrate, zinc chloride, zinc sulfate, zinc gluconate, zinc lactate, zinc phosphate, zinc oxide, zinc carbonate, or combinations thereof.

20. The oral care composition of claim 14 , wherein the composition comprises from 0.01% to 5%, by weight of the composition, of a thickening agent selected from a thickening polymer, a thickening silica, or a combination thereof.

21. The oral care composition of claim 14 , wherein the composition comprises from 1% to 60%, by weight of the composition, of a humectant.

22. The oral care composition of claim 21 , wherein the humectant comprises glycerin, sorbitol, or combinations thereof.

23. The oral care composition of claim 14 , wherein the composition comprises abrasive.

24. The oral care composition of claim 23 , wherein the abrasive comprises silica abrasive, calcium-containing abrasive or combinations thereof.

25. The oral care composition of claim 24 , wherein the silica abrasive comprises precipitated silica.

26. The oral care composition of claim 24 , wherein the calcium-containing abrasive comprises calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcium orthophosphate, calcium metaphosphate, calcium polyphosphate, calcium oxyapatite, sodium carbonate, sodium bicarbonate, or combinations thereof.

Assignees

• Procter & Gamble

Inventors

• Strand Ross
• Shi Yunming
• Su Yang

Classifications

• A61K8/27

  Zinc; Compounds thereof · CPC title

• A61K8/365

  Hydroxycarboxylic acids; Ketocarboxylic acids · CPC title

• A61K8/442

  substituted by amido group(s) · CPC title

• A61K8/21 Primary

  Fluorides; Derivatives thereof · CPC title

• A61K8/44 Primary

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title