Oral care composition

Patent metadata

Field	Value
Publication number	US-9532932-B2
Application number	US-201414147826-A
Country	US
Kind code	B2
Filing date	Jan 6, 2014
Priority date	Mar 31, 2010
Publication date	Jan 3, 2017
Grant date	Jan 3, 2017

Abstract

Disclosed are oral care compositions, for example dentifrice compositions, comprising an oral care composition comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and at least one amino acid capable of chelating the metal oxide. The composition may comprise a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide.

First claim

The invention claimed is:

1. An oral care composition comprising:
an orally acceptable vehicle;
a source of metal oxide particles, wherein said metal oxide particles have a median particle size of from 1 to 7 microns;

one or more amino acids capable of chelating said metal oxide particles selected from arginine, L-arginine, cysteine, leucine, isoleucine, lysine, L-lysine and serine, wherein the metal oxide comprises zinc oxide; and
further comprising a polymeric adherent material, wherein the metal oxide is encapsulated in the polymeric adherent material.

2. The oral care composition according to claim 1 wherein the metal oxide particles have a median particle size of 5 microns or less.

3. The oral care composition according to claim 1 wherein the metal oxide particles have a particle size distribution of 3 to 4 microns, a particle size distribution of 5 to 7 microns, a particle size distribution of 3 to 5 microns, a particle size distribution of 2 to 5 microns, or a particle size distribution of 2 to 4 microns.

4. The oral care composition according to claim 1 wherein the metal oxide particles are present in an amount of up to 5% by weight, based on the total weight of the oral care composition.

5. The oral care composition according to claim 3 wherein the metal oxide particles are present in an amount of from 0.5 to 2% by weight, based on the total weight of the oral care composition.

6. The oral care composition according to claim 1 wherein the source of metal oxide particles is selected from a powder, a nanoparticle solution; a nanoparticle suspension; a capsule; and a bead.

7. The oral care composition according to claim 1 wherein at least one of said one or more amino acids is L-arginine.

8. The oral care composition according to claim 1 wherein at least one of said one or more amino acids is present in an amount of up to 5% by weight, based on the total weight of the oral care composition.

9. The oral care composition according to claim 7 wherein at least one of said one or more amino acids is present in an amount of from 0.5 to 5% by weight, based on the total weight of the oral care composition.

10. The oral care composition according to claim 8 wherein at least one of said one or more amino acids is present in an amount of from 2.5 to 4.5% by weight, based on the total weight of the oral care composition.

11. The oral care composition according to claim 1 wherein the polymeric adherent material comprises one or more cellulose polymers.

12. The oral care composition according to claim 11 wherein at least one of said one or more cellulose polymers is a hydroxyalkyl cellulose polymer selected from hydroxypropylmethyl cellulose (HPMC), hydroxyethylpropyl cellulose (HEPC), hydroxybutylmethyl cellulose (HBMC), and carboxymethyl cellulose (CMC).

13. The oral care composition according to claim 12 wherein the polymeric adherent material comprises a mixture of two hydroxyalkyl cellulose polymers having different molecular weights and the metal oxide comprises zinc oxide which is encapsulated in the mixture of two hydroxyalkyl cellulose polymers.

14. The oral care composition according to claim 1 wherein the polymeric adherent material comprises one or more polymers selected from a poly (ethylene oxide) polymer, polyvinylpyrrolidone (PVP), polyethylene glycol (PEG)/polypropylene glycol (PPG) copolymer, ethylene oxide (EO)-propylene oxide (PO) block copolymers, ester gum, shellac, pressure sensitive silicone adhesives, methacrylates, or mixtures thereof.

15. The oral care composition according to claim 1 which is a dentifrice composition.

16. The oral care composition according to claim 15 , which is a toothpaste or a gel.

17. The oral care composition according to claim 1 , wherein the composition is formulated into a form selected from a mouth rinse, a gum, a dissolvable lozenge, and a dissolvable film.

18. A method of reducing dental sensitivity comprising applying to the surface of a mammalian tooth an oral care composition of claim 1 .

19. A method of protecting dental surfaces from acid-mediated degradation, comprising applying to the surface of a mammalian tooth an oral care composition of claim 1 .

20. A method of maintaining or increasing the systemic health of a mammal comprising applying a composition to an oral surface of a mammal at least once a day for a duration of time, wherein the composition comprises:
a. an oral care composition of claim 1 , and
b. an agent selected from triclosan; triclosan monophosphate; chlorhexidine;
alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl-4ethylpyridinium chloride (TDEPC); octenidine; delmopinol; octapinol; nisin; zinc ion agent; copper ion agent; essential oils; furanones; bacteriocins, ethyllauroyl arginate, extracts of magnolia, a metal ion source, fluoride, stannous ions, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morn, extract of sea buckthorn, a peroxide, an enzyme, a Camellia extract, a flavonoid, a flavan, halogenated diphenyl ether, creative, and propolis.

21. A method of occluding a dentin tubule within the surface of a mammalian tooth comprising applying to the tooth surface a composition according to claim 1 .

22. An oral care composition according to claim 1 and further comprising an agent selected from triclosan; triclosan monophosphate; chlorhexidine; alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl-4ethylpyridinium chloride (TDEPC); octenidine; delmopinol; octapinol; nisin; zinc ion agent; copper ion agent; essential oils; furanones; bacteriocins, ethyllauroyl arginate, extracts of magnolia, a metal ion source, fluoride, stannous ions, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morn, extract of sea buckthorn, a peroxide, an enzyme, a Camellia extract, a flavonoid, a flavan, halogenated diphenyl ether, creative, and propolis, for use in a method of maintaining or increasing the systemic health of a mammal.

23. The oral care composition according to claim 13 wherein the metal oxide particles are present in an amount of from 0.5 to 2% by weight, based on the total weight of the oral care composition.

24. The oral care composition according to claim 23 wherein at least one of said one or more amino acids is present in an amount of from 0.5 to 5% by weight, based on the total weight of the oral care composition.

25. The oral care composition according to claim 24 wherein at least one of said one or more amino acids is L-arginine.

26. The oral care composition of claim 1 , further comprising stannous fluoride.

Assignees

• Colgate Palmolive Co

Inventors

• Prencipe Michael
• Morgan Andre
• Maloney Venda Porter

Classifications

• A61K8/27 Primary

  Zinc; Compounds thereof · CPC title

• A61K2800/5922

  At least two compounds being classified in the same subclass of A61K8/18 · CPC title

• A61Q11/00

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K2800/594

  Mixtures of polymers · CPC title

• A61K8/19

  containing inorganic ingredients · CPC title