Lyophilization

Patent metadata

Field	Value
Publication number	US-10976105-B2
Application number	US-202016736430-A
Country	US
Kind code	B2
Filing date	Jan 7, 2020
Priority date	Jun 9, 2014
Publication date	Apr 13, 2021
Grant date	Apr 13, 2021

Abstract

Embodiments of methods, systems, and apparatuses for lyophilizing, storing, and transfusing materials are described. In embodiments, the materials may include whole blood or a component of whole blood such as plasma.

First claim

What is claimed is:

1. A method of preparing a liquid comprising a blood component for lyophilization, the method comprising:
pooling a plurality of volumes of liquid comprising a blood component to generate a pooled volume of liquid;
removing a portion of liquid from the pooled volume of liquid to create a reduced volume of liquid; and
filling a plurality of containers with the reduced volume of liquid, wherein the plurality of containers comprise a wall that is permeable to water vapor.

2. The method of claim 1 , further comprising reducing pathogens in the reduced volume of liquid.

3. The method of claim 2 , wherein the reducing pathogens comprises:
adding a photosensitizer to the reduced volume of liquid; and
exposing the photosensitizer and the reduced volume of liquid to a light source.

Assignees

• Terumo Bct Inc

Inventors

• Corbin Iii Frank
• Hlavinka Dennis J
• Pareta Rajesh
• Hillam Mark E

Classifications

• A61L2103/09

  Blood or products thereof · CPC title

• A01N1/165

  Pressure processes, e.g. following predefined pressure changes over time · CPC title

• A01N1/162

  Temperature processes, e.g. following predefined temperature changes over time · CPC title

• A01N1/146

  Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving · CPC title

• A01N1/144

  for temperature control, e.g. refrigerators or freeze-drying apparatus · CPC title