FFL-based magnetic particle imaging three-dimensional reconstruction method, system, and device

Patent metadata

Field	Value
Publication number	US-10939845-B2
Application number	US-202016907334-A
Country	US
Kind code	B2
Filing date	Jun 22, 2020
Priority date	Jul 15, 2019
Publication date	Mar 9, 2021
Grant date	Mar 9, 2021

Abstract

A FFL-based magnetic particle imaging three-dimensional reconstruction method includes: acquiring current signal data of an induction coil during FFL-based three-dimensional scanning process of a scanned object; based on the current signal data, performing deconvolution through a preset kernel function to acquire a two-dimensional image data set, wherein the kernel function is a step function with L2 regularized constraint; based on the two-dimensional image data set, acquiring an initial three-dimensional image by using a Wiener filtering deconvolution algorithm; and based on the initial three-dimensional image, performing deconvolution through a Langevin function, and acquiring a final three-dimensional image by Radon transformation. A FFL-based magnetic particle imaging three-dimensional reconstruction system includes a magnet group, an induction coil, an imaging bed, and a control and imaging device, wherein, a magnetic particle imaging method in the control and imaging device is the FFL-based magnetic particle imaging three-dimensional reconstruction method.

First claim

What is claimed is:

1. A FFL-based magnetic particle imaging three-dimensional reconstruction method, comprising the following steps:
step S 100 , acquiring current signal data of an induction coil during FFL-based three-dimensional scanning process of a scanned object;
step S 200 , based on the current signal data, performing deconvolution through a preset kernel function to acquire a two-dimensional image data set, wherein the preset kernel function is a step function with L2 regularized constraint that approximates a point spread function;
step S 300 , based on the two-dimensional image data set, acquiring an initial image by using a Wiener filtering deconvolution algorithm; and
step S 400 , based on the initial image, performing deconvolution through a Langevin function, and acquiring a final three-dimensional image by Radon transformation; wherein the method is used in medical applications to accurately locate magnetic particles in the final three-dimensional image.

2. The FFL-based magnetic particle imaging three-dimensional reconstruction method of claim 1 , wherein, the step S 100 of acquiring the current signal data of the induction coil during the FFL-based three-dimensional scanning process of the scanned object comprises:
adopting a FFL-based magnetic particle imaging system to perform three-dimensional scanning on the scanned object by rotation and displacement of FFL; and
acquiring the current signal data of the induction coil in the FFL-based magnetic particle imaging system during the FFL-based three-dimensional scanning process.

3. The FFL-based magnetic particle imaging three-dimensional reconstruction method of claim 1 , wherein, before the step S 200 of performing deconvolution through the preset kernel function, the FFL-based magnetic particle imaging three-dimensional reconstruction method further comprises: performing analog-to-digital conversion on the current signal data.

4. A FFL-based magnetic particle imaging three-dimensional reconstruction system, comprising a magnet group, an induction coil, an imaging bed, and a control and imaging device, wherein, a magnetic particle imaging method in the control and imaging device is the FFL-based magnetic particle imaging three-dimensional reconstruction method of claim 1 .

5. A storage device, storing a plurality of programs, wherein, the plurality of programs are configured to be loaded and executed by a processor to implement the FFL-based magnetic particle imaging three-dimensional reconstruction method of claim 1 .

6. A processing device, comprising a processor and a storage device, wherein, the processor is configured to execute a plurality of programs, the storage device is configured to store the plurality of programs, and the plurality of programs are configured to be loaded and executed by the processor to implement the FFL-based magnetic particle imaging three-dimensional reconstruction method of claim 1 .

7. The FFL-based magnetic particle imaging three-dimensional reconstruction system of claim 4 , wherein, the step S 100 of acquiring the current signal data of the induction coil during the FFL-based three-dimensional scanning process of the scanned object comprises:
adopting a FFL-based magnetic particle imaging system to perform three-dimensional scanning on the scanned object by rotation and displacement of FFL; and
acquiring the current signal data of the induction coil in the FFL-based magnetic particle imaging system during the FFL-based three-dimensional scanning process.

8. The FFL-based magnetic particle imaging three-dimensional reconstruction system of claim 4 , wherein, before the step S 200 of performing deconvolution through the preset kernel function, the FFL-based magnetic particle imaging three-dimensional reconstruction method further comprises: performing analog-to-digital conversion on the current signal data.

9. The storage device of claim 5 , wherein, the step S 100 of acquiring the current signal data of the induction coil during the FFL-based three-dimensional scanning process of the scanned object comprises:
adopting a FFL-based magnetic particle imaging system to perform three-dimensional scanning on the scanned object by rotation and displacement of FFL; and
acquiring the current signal data of the induction coil in the FFL-based magnetic particle imaging system during the FFL-based three-dimensional scanning process.

10. The storage device of claim 5 , wherein, before the step S 200 of performing deconvolution through the preset kernel function, the FFL-based magnetic particle imaging three-dimensional reconstruction method further comprises: performing analog-to-digital conversion on the current signal data.

11. The processing device of claim 6 , wherein, the step S 100 of acquiring the current signal data of the induction coil during the FFL-based three-dimensional scanning process of the scanned object comprises:
adopting a FFL-based magnetic particle imaging system to perform three-dimensional scanning on the scanned object by rotation and displacement of FFL; and
acquiring the current signal data of the induction coil in the FFL-based magnetic particle imaging system during the FFL-based three-dimensional scanning process.

12. The processing device of claim 6 , wherein, before the step S 200 of performing deconvolution through the preset kernel function, the FFL-based magnetic particle imaging three-dimensional reconstruction method further comprises: performing analog-to-digital conversion on the current signal data.

Assignees

• Inst Automation Cas

Inventors

• Tian Jie
• Zhang Peng
• Hui Hui
• Wang Kun
• Yang Xin

Classifications

• G06T12/20 Primary

  Inverse problem, i.e. transformations from projection space into object space · CPC title

• A61B5/0515 Primary

  Magnetic particle imaging · CPC title

• A61B5/72

  Signal processing specially adapted for physiological signals or for diagnostic purposes · CPC title

• A61B5/7225

  Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation (input circuits for detecting, measuring, or recording bioelectric or biomagnetic signals A61B5/30; specific diagnostic methods using bioelectric or biomagnetic signals A61B5/316) · CPC title