Hydrogel compositions for use in cell expansion and differentiation
US-2017246357-A1 · Aug 31, 2017 · US
Wet adhesive peptide materials and their use
US10927148B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10927148-B2 |
| Application number | US-201816182425-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 6, 2018 |
| Priority date | Nov 6, 2017 |
| Publication date | Feb 23, 2021 |
| Grant date | Feb 23, 2021 |
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- Title
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Abstract
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Peptides that form adhesive bonds, even in aqueous and/or saline environments, are disclosed. When aggregated, the peptides may be used in methods for producing hydrogels and/or adhesive materials. Synthetic peptide analogs are provided that are designed based on protein sequences found in barnacle adhesive, and may optionally be augmented with chemistry from other organisms that secrete proteins that adhere to substrates. The peptides may be used, for example, in biomedical and aqueous applications. Methods of using the aggregated peptides as adhesives are also provided.
First claim
Opening claim text (preview).
What is claimed: 1. A method for forming a wet adhesive, comprising: providing a first surface; covering at least a portion of the first surface with a first peptide comprising an amino acid sequence of any one of SEQ ID Nos:1-8; and introducing a second peptide in contact with the first peptide, wherein upon contact of the first peptide with the second peptide, the first peptide and second peptide self-assemble into a solid adhesive material. 2. The method of claim 1 , wherein the second peptide comprises an amino acid sequence of any one of SEQ ID Nos: 2, 5 and 6. 3. The method of claim 1 , wherein the peptides are applied in a vehicle comprising a water immiscible solvent. 4. The method of claim 3 , wherein the water immiscible solvent is selected from the group consisting of non-polar solvents, oils, and lipids. 5. The method of claim 1 , wherein the second peptide is provided on a second surface. 6. The method of claim 4 , wherein the aqueous environment is a body of water selected from the group consisting of oceans, lakes, and rivers.
Assignees
Inventors
Classifications
characterised by using adhesives · CPC title
Adhesives based on proteins; Adhesives based on derivatives thereof · CPC title
Presence of protein · CPC title
- C07K14/001Primary
by chemical synthesis · CPC title
involving separate application of adhesive ingredients to the different surfaces to be joined · CPC title
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Frequently asked questions
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- What does patent US10927148B2 cover?
- Peptides that form adhesive bonds, even in aqueous and/or saline environments, are disclosed. When aggregated, the peptides may be used in methods for producing hydrogels and/or adhesive materials. Synthetic peptide analogs are provided that are designed based on protein sequences found in barnacle adhesive, and may optionally be augmented with chemistry from other organisms that secrete protei…
- Who is the assignee on this patent?
- Us Gov Sec Navy
- What technology area does this patent fall under?
- Primary CPC classification C07K14/001. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 23 2021 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 4 related publications on this page (citations in our corpus or others sharing the same primary CPC).