Cannula for minimizing dilution of dosing during nitric oxide delivery

Patent metadata

Field	Value
Publication number	US-10918819-B2
Application number	US-201715790300-A
Country	US
Kind code	B2
Filing date	Oct 23, 2017
Priority date	Dec 4, 2012
Publication date	Feb 16, 2021
Grant date	Feb 16, 2021

Abstract

Described are nasal cannulas that improve the precision of the delivered dose for nitric oxide therapy by reducing the dilution of nitric oxide. The nasal cannulas may reduce the total volume and potential for retrograde flow during nitric oxide therapy through the design of the specific dimensions of the flow path and/or having check valves in the nitric oxide delivery line and/or having a flapper or umbrella valve dedicated to nitric oxide delivery. The nasal cannulas may also use materials that limit oxygen diffusion through the cannula walls. The nosepiece for these cannulas may be manufactured by a molding technique.

First claim

What is claimed is:

1. A method of administering nitric oxide for treating pulmonary hypertension, the method comprising:
administering a pulse of a gas comprising nitric oxide to a patient in need thereof, wherein the pulse is administered through a nasal cannula comprising a cannula nosepiece comprising a nitric oxide flow path having a volume that is less than 20% of a volume of pulse of the gas comprising nitric oxide.

2. The method of claim 1 , wherein the nasal cannula comprises:
a first lumen, a second lumen, and a third lumen:
the first lumen being a first therapeutic gas lumen for delivering the gas comprising nitric oxide to the patient,
the second lumen being a triggering lumen, and
the third lumen being a second therapeutic gas lumen for delivering a gas comprising oxygen to the patient; and

wherein the cannula nosepiece has separate flow paths to the patient for each of (i) the first therapeutic gas lumen, (ii) the triggering lumen, and (iii) the second therapeutic gas lumen.

3. The method of claim 1 , wherein the nitric oxide flow path comprises a first prong, a second prong and a prong spacing.

4. The method of claim 1 , wherein the nasal cannula comprises a first lumen for delivering the gas comprising nitric oxide to the patient and a second lumen, wherein the first lumen has a smaller inner diameter than an inner diameter of the second lumen.

5. The method of claim 1 , wherein the pulse of gas comprising nitric oxide has a volume less than 1 mL.

6. The method of claim 1 , wherein the nitric oxide flow path is less than 10% of the volume of pulse of the gas comprising nitric oxide.

7. The method of claim 1 , wherein the nitric oxide flow path has a volume less than or equal to 0.035 mL.

8. A method of administering nitric oxide for treating pulmonary hypertension, the method comprising:
administering a plurality of pulses of a gas comprising nitric oxide to a patient in need thereof, wherein the plurality of pulses are administered through a nasal cannula comprising a cannula nosepiece comprising a nitric oxide flow path having a volume that is less than 20% of a volume of each of the plurality of pulses of the gas comprising nitric oxide.

9. The method of claim 8 , wherein the nasal cannula comprises:
a first lumen, a second lumen, and a third lumen:
the first lumen being a first therapeutic gas lumen for delivering a gas comprising nitric oxide to the patient,
the second lumen being a triggering lumen, and
the third lumen being a second therapeutic gas lumen for delivering a gas comprising oxygen to the patient; and

wherein the cannula nosepiece has separate flow paths to the patient for each of (i) the first therapeutic gas lumen, (ii) the triggering lumen, and (iii) the second therapeutic gas lumen.

10. The method of claim 8 , wherein the nitric oxide flow path comprises a first prong, a second prong and a prong spacing.

11. The method of claim 8 , wherein the nasal cannula comprises a first lumen for delivering the gas comprising nitric oxide to the patient and a second lumen, wherein the first lumen has a smaller inner diameter than an inner diameter of the second lumen.

12. The method of claim 8 , wherein each of the plurality of pulses of the gas comprising nitric oxide has a volume less than 1 mL.

13. The method of claim 8 , wherein the nitric oxide flow path is less than 10% of the volume of each of the plurality of pulses of the gas comprising nitric oxide.

14. The method of claim 8 , wherein the nitric oxide flow path has a volume less than or equal to 0.035 mL.

15. A method of administering nitric oxide to a patient, the method comprising:
administering a plurality of pulses of a gas comprising nitric oxide to the patient, wherein the plurality of pulses are administered through a nasal cannula comprising a cannula nosepiece comprising a nitric oxide flow path having a volume that is less than 20% of a volume of each of the plurality of pulses of the gas comprising nitric oxide.

16. The method of claim 15 , wherein the nasal cannula comprises:
a first lumen, a second lumen, and a third lumen:
the first lumen being a first therapeutic gas lumen for delivering a gas comprising nitric oxide to the patient,
the second lumen being a triggering lumen, and
the third lumen being a second therapeutic gas lumen for delivering a gas comprising oxygen to the patient; and

wherein the cannula nosepiece has separate flow paths to the patient for each of (i) the first therapeutic gas lumen, (ii) the triggering lumen, and (iii) the second therapeutic gas lumen.

17. The method of claim 15 , wherein the nitric oxide flow path comprises a first prong, a second prong and a prong spacing.

18. The method of claim 15 , wherein the nasal cannula comprises a first lumen for delivering the gas comprising nitric oxide to the patient and a second lumen, wherein the first lumen has a smaller inner diameter than an inner diameter of the second lumen.

19. The method of claim 15 , wherein each of the plurality of pulses of the gas comprising nitric oxide has a volume less than 1 mL.

20. The method of claim 15 , wherein the nitric oxide flow path is less than 10% of the volume of each of the plurality of pulses of the gas comprising nitric oxide.

Assignees

• Mallinckrodt Hospital Products Ip Ltd

Inventors

• Flanagan Craig
• Freed Simon
• Klaus John
• Kohlmann Thomas
• Meglasson Martin D
• Naidu Manesh
• Shah Parag

Classifications

• A61M16/208

  Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves · CPC title

• A61M2202/0208

  Oxygen · CPC title

• A61M16/0677 Primary

  Gas-saving devices therefor · CPC title

• A61M16/06

  Respiratory or anaesthetic masks · CPC title

• A61M16/0858

  Pressure sampling ports · CPC title