Cannula for minimizing dilution of dosing during nitric oxide delivery

Patent metadata

Field	Value
Publication number	US-9550039-B2
Application number	US-201414312003-A
Country	US
Kind code	B2
Filing date	Jun 23, 2014
Priority date	Dec 4, 2012
Publication date	Jan 24, 2017
Grant date	Jan 24, 2017

Abstract

The present invention generally relates to, amongst other things, systems, devices, materials, and methods that can improve the accuracy and/or precision of nitric oxide therapy by, for example, reducing the dilution of inhaled nitric oxide (NO). As described herein, NO dilution can occur because of various factors. To reduce the dilution of an intended NO dose, various exemplary nasal cannulas, pneumatic configurations, methods of manufacturing, and methods of use, etc. are disclosed.

First claim

What is claimed is:

1. A nasal cannula for therapeutic gas delivered to a patient in need thereof, comprising:
a first lumen, a second lumen, and a third lumen:
the first lumen being a first therapeutic gas lumen for delivering a first therapeutic gas comprising nitric oxide to a patient in need thereof,
the second lumen being a triggering lumen, and
the third lumen being a second therapeutic gas lumen for delivering a second therapeutic gas comprising oxygen to the patient; and

a cannula nosepiece allowing separate flow paths to the patient for (i) the first therapeutic gas lumen, (ii) the triggering lumen, and (iii) the second therapeutic gas lumen; and
wherein the first lumen has an inner diameter that is smaller than inner diameters of the second lumen and third lumen but larger than an inner diameter of the flow path for the first lumen at the cannula nosepiece.

2. The nasal cannula of claim 1 , wherein the nasal cannula (i) reduces dilution of one or more of the first and second therapeutic gases delivered to the patient or (ii) is configured to be placed in fluid communication with at least one system to deliver one or more of the first and second therapeutic gases to the patient, or both.

3. The nasal cannula of claim 1 , wherein the nasal cannula at least one of inhibits mixing of nitric oxide and oxygen and reduces delivery of nitrogen dioxide to the patient.

4. The nasal cannula of claim 1 , wherein the nasal cannula delivers one or more of the first and second therapeutic gases to the patient for treatment of pulmonary hypertension.

5. The nasal cannula of claim 1 , wherein the nasal cannula delivers one or more of the first and second therapeutic gases to the patient for treatment of at least one of pulmonary hypertension secondary to chronic obstructive pulmonary disease (COPD), pulmonary hypertension as pulmonary arterial hypertension (PAH), pulmonary hypertension secondary to idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension secondary to sarcoidosis.

6. The nasal cannula of claim 1 , wherein the first therapeutic gas lumen for delivering nitric oxide is about six feet to about eight feet in length having an inner diameter of about 0.01 inches to about 0.10 inches.

7. The nasal cannula of claim 1 , wherein the cannula nosepiece comprises a nitric oxide flow path having a volume that is less than about 25% of a minimum pulse volume of the pulse of nitric oxide.

8. The nasal cannula of claim 1 , wherein the cannula comprises a wall material having a low oxygen transmission rate that is between

0.001
⁢

(
cc
)

⁢

(
mil
)

(

24
⁢

⁢
hrs

)

⁢

(

100
⁢

⁢

in
2

)

⁢

(
ATM
)

and

10
⁢

(
cc
)

⁢

(
mil
)

(

24
⁢

⁢
hrs

)

⁢

(

100
⁢

⁢

in
2

)

⁢

(
ATM
)

.

9. The nasal cannula of claim 1 , wherein the cannula is further comprising a fourth lumen:
the fourth lumen being another first therapeutic gas lumen for delivering the first therapeutic gas to the patient; and
wherein the first lumen delivers the first therapeutic gas to one nostril of the patient and the fourth lumen delivers the first therapeutic gas to another nostril of the patient.

10. The nasal cannula of claim 1 , further comprising one or more of: (i) at least one check valve in fluid communication with the first therapeutic gas lumen, (ii) a cannula key, (iii) a scavenging material, and (iv) a flexible support bridge.

11. A nasal cannula for therapeutic gas delivered to a patient in need thereof, comprising:
a first lumen, a second lumen, and a third lumen:
the first lumen being a first therapeutic gas lumen for delivering a first therapeutic gas comprising nitric oxide to a patient,
the second lumen being a triggering lumen for triggering release of a pulse of the first therapeutic gas, and
the third lumen being a second therapeutic gas lumen for delivering a second therapeutic gas comprising oxygen to the patient;

the first therapeutic gas lumen, the triggering lumen, and the second therapeutic gas lumen aggregating at a cannula nosepiece, the cannula nosepiece allowing separate flow paths to the patient for each of the first therapeutic gas lumen, the triggering lumen, and the second therapeutic gas lumen; and
the first therapeutic gas lumen having an inner diameter that is (i) smaller than an inner diameter of the second therapeutic gas lumen and an inner diameter of the triggering lumen and (ii) larger than an inner diameter of the flow path for the first therapeutic gas lumen at the cannula nosepiece.

12. The nasal cannula of claim 11 , wherein the nasal cannula (i) reduces dilution of one or more of the first and second therapeutic gases delivered to the patient or (ii) is configured to be placed in fluid communication with at least one system to deliver one or more of the first and second therapeutic gases to the patient, or both.

13. The nasal cannula of claim 11 , wherein the nasal cannula at least one of inhibits mixing of nitric oxide and oxygen and reduces delivery of nitrogen d

Assignees

• Mallinckrodt Hospital Products Ip Ltd

Inventors

• Flanagan Craig
• Freed Simon
• Klaus John
• Kohlmann Thomas
• Meglasson Martin D
• Naidu Manesh
• Shah Parag

Classifications

• A61M16/10

  Preparation of respiratory gases or vapours · CPC title

• A61M2016/0021

  with a proportional output signal, e.g. from a thermistor · CPC title

• A61M16/009

  Removing used or expired gases or anaesthetic vapours (filtering, sterilising or disinfecting the exhaust air in drainage systems A61M1/784; bacterial filters in the expiratory path A61M16/1065) · CPC title

• A61M16/104

  specially adapted for anaesthetics (A61M16/18 takes precedence) · CPC title

• A61M2202/0283

  Nitrous oxide (N2O) · CPC title