Fluid handling method to switch a valve device or to temporarily counteract a flow

Patent metadata

Field	Value
Publication number	US-10906041-B2
Application number	US-201816181043-A
Country	US
Kind code	B2
Filing date	Nov 5, 2018
Priority date	May 6, 2016
Publication date	Feb 2, 2021
Grant date	Feb 2, 2021

Abstract

A fluid handling device has fluidic structures having inlet and outlet chambers and a connecting duct fluidically connecting the two. In a first state, the inlet chamber is completely or partly filled with at least a liquid and partly filled with a compressible medium, and the outlet chamber is at least partly filled with the compressible medium. One of the inlet chamber and the outlet chamber has such a venting duct that a flow resistance/volume product of venting of the chamber for the compressible medium amounts to at least 6700 N·s/m2, the other of the inlet chamber and of the outlet chamber being vented. An actuator for actuating the fluidic structures is to cause a pressure difference of at least 30 Pa between the compressible media within the inlet and outlet chambers, so as to thereby switch a valve device implemented into the connecting duct.

First claim

The invention claimed is:

1. Fluid handling method comprising:
providing a fluid handling device comprising:
microfluidic structures comprising at least one inlet chamber, one outlet chamber, and a connecting duct which fluidically connects the inlet chamber to the outlet chamber,
wherein in an initial state, the inlet chamber is completely filled with at least a liquid or partly filled with at least a liquid and partly filled with a compressible medium, and the outlet chamber is at least partly filled with the compressible medium,
wherein one of the inlet chamber and the outlet chamber comprises a venting duct so that a flow resistance/volume product of venting of said chamber for the compressible medium amounts to at least

6700
⁢

N
·
s

m
2

,
,

the other of the inlet chamber and of the outlet chamber being vented,
wherein the respective flow resistance/volume product is defined by the product resulting from the volume of the respective chamber and a fluidic resistance R fl of the respective venting duct, comprising

R
fl

=

C
geometry

·

η
⁢

⁢
l

A
2

wherein C geometry is a geometry-dependent factor, η is the viscosity of the compressible medium, l is the length of the respective venting duct, and A is the cross sectional area of the respective venting duct; and
starting from the initial state, actuating the microfluidic structures by effecting a temperature change of the compressible medium or by increasing a rotational frequency at which the microfluidic structures are rotated so as to cause, due to different pressure equalization rates of the inlet chamber and of the outlet chamber, a pressure difference of at least 30 Pa between the compressible medium within the inlet chamber and the compressible medium within the outlet chamber so as to thereby switch a valve device implemented into the connecting duct, such that liquid gets from the inlet chamber into the outlet chamber, or so as to thereby temporarily counteract a flow, caused by the actuating, from the inlet chamber into the outlet chamber.

2. Fluid handling method as claimed in claim 1 , wherein the fluid handling device is provided such that the flow resistance/volume product is a first flow resistance/volume product, the other of the inlet chamber and of the outlet chamber comprising a venting duct and, thus, a second flow resistance/volume product of the venting of said other chamber for the compressible medium, the first flow resistance/volume product being at least four times larger than the second flow resistance/volume product.

3. Fluid handling method as claimed in claim 1 , wherein the fluid handling device is provided such that the microfluidic structures are formed within a fluidic module which represents a body of rotation or may be inserted into a body of rotation, wherein the fluid handling device further comprises a drive unit configured to subject the fluidic module and, thus, the microfluidic structures to rotation.

4. Fluid handling device as claimed in claim 1 , wherein the fluid handling device is provided such that the connecting duct comprises a siphon or a capillary valve.

5. Method as claimed in claim 1 , wherein the chamber whose flow resistance/volume product of the venting of said chamber for the compressible medium amounts to at least

6700
⁢

N
·
s

m
2

is the inlet chamber, wherein said actuating causes a pressure increase of the compressible medium so that due to a delay in pressure equalization within the inlet chamber, an excess pressure of at least 30 Pa in the compressible medium within the inlet chamber is temporarily caused as compared to the compressible medium within the outlet chamber.

6. Method as claimed in claim 5 , wherein said actuating comprises heating of the compressible medium at a heating rate of ≥0.1 K/s.

7. Method as claimed in claim 6 , wherein the heating of the compressible medium comprises heating the ambient air.

8. Method as claimed in claim 6 , wherein the heating of the compressible medium is caused locally within the inlet chamber and/or the outlet chamber.

9. Method as claimed in claim 1 , wherein the chamber whose flow resistance/volume product of the venting of said chamber for the compressible medium amounts to at least

6700
⁢

N
·
s

m
2

is the outlet chamber, wherein said actuating causes a pressure decrease of the compressible medium so that due to a delay in pressure equalization within the outlet chamber, a negative pressure of at least 30 Pa in the compressible medium within the outlet chamber is temporarily caused as compared to the compressible medium within the inlet chamber.

10. Method as claimed in claim 9 , wherein said actuating comprises cooling of the compressible medium at a cooling rate of ≥0.1 K/s.

11. Method as claimed in claim 10 , wherein the cooling of the compressible medium is caused by cooling the ambient air.

12. Method as claimed in claim 10 , wherein the cooling of the compressible medium is caused locally within the inlet chamber and/or the outlet chamber.

13. Method as claimed in claim 1 , wherein the chamber whose flow resistance/volume product of the venting of said chamber for the compressible medium amounts to at least

6700
⁢

N
·
s

m
2

is the outlet chamber, and wherein the pressure difference is caused by mechanical compression of the compressible medium within the outlet chamber.

14. Method as claimed in claim 13 , wherein said actuating comprises subjecting the liquid within the inlet chamber to a force by which the liquid is driven into the connecting duct, wherein an increase in pressure in the compressible medium within the outlet chamber is caused by mechanical compression of the com

Assignees

• Hahn Schickard Ges Fuer Angewandte Forschung E V

Inventors

• Czilwik Gregor
• Keller Mark
• Paust Nils
• Hutzenlaub Tobias

Classifications

• B01F33/3033

  using heat to mix or move the fluids · CPC title

• F16K2099/0084

  Chemistry or biology, e.g. "lab-on-a-chip" technology · CPC title

• B01L2400/0694

  vents used to stop and induce flow, backpressure valves · CPC title

• B01L2400/0409

  centrifugal forces · CPC title

• B01L3/502723 Primary

  characterised by venting arrangements · CPC title