Rotatable cartridge with a metering chamber for analyzing a biological sample
US-9868120-B2 · Jan 16, 2018 · US
US10001125B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10001125-B2 |
| Application number | US-201414459530-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 14, 2014 |
| Priority date | Feb 23, 2012 |
| Publication date | Jun 19, 2018 |
| Grant date | Jun 19, 2018 |
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A fluidics module rotatable about a rotational center includes first and second chambers and a compression chamber. First and second fluid channels are provided between the first and second chambers and the compression chamber, respectively. The flow resistance of the second fluid channel is smaller, for a flow of liquid from the compression chamber to the second chamber, than a flow resistance of the first fluid channel for a flow of liquid from the compression chamber to the first chamber. Upon rotation at a high rotational frequency, liquid is initially introduced from the first chamber into the compression chamber via the first fluid channel, so that a compressible medium is compressed within the compression chamber. Subsequently, the rotational frequency is reduced, so that the compressible medium within the compression chamber will expand and so that, thereby, liquid is driven into the second chamber via the second fluid channel.
Opening claim text (preview).
The invention claimed is: 1. A device for pumping a liquid, comprising: a fluidics module rotatable about a rotational center, the fluidics module comprising: a first chamber including a fluid outlet; a compression chamber; a second chamber including a fluid inlet; a first fluid channel between the fluid outlet of the first chamber and the compression chamber; a second fluid channel between the compression chamber and the fluid inlet of the second chamber, wherein a liquid may be centrifugally driven through the first fluid channel from the first chamber into the compression chamber, wherein the second fluid channel includes at least one portion whose beginning is located further outward radially than its end, wherein a flow resistance of the second fluid channel for a flow of liquid from the compression chamber to the second chamber is smaller than a flow resistance of the first fluid channel for a flow of liquid from the compression chamber to the first chamber, wherein, upon rotation of the fluidics module, a compressible medium within the compression chamber may be trapped and compressed by a liquid driven from the first chamber into the compression chamber by centrifugal force, and wherein liquid may be driven into the second chamber from the compression chamber through the second fluid channel by a reduction of the rotational frequency and by consequent expansion of the compressible medium, wherein the compression chamber permits the liquid driven from the first chamber into the compression chamber by centrifugal force to trap and compress the compressible medium in the compression chamber, a drive configured to: subject the fluidics module to such a rotational frequency, in a first phase, that liquid is driven from the first chamber through the first fluid channel into the compression chamber, where a compressible medium is thus trapped and compressed, filling levels of the liquid in the first fluid channel, the compression chamber and the second fluid channel adopting a state of equilibrium, and reduce the rotational frequency in a second phase such that the compressible medium within the compression chamber will expand and thereby drive liquid from the compression chamber through the second fluid channel into the second chamber; and a unit for supporting expansion of the compressible medium upon reduction of the rotational frequency. 2. The device as claimed in claim 1 , wherein a flow cross-section of the second fluid channel is larger than a flow cross-section of the first fluid channel. 3. The device as claimed in claim 1 , wherein the fluid inlet of the second chamber is located further inward radially than the fluid outlet of the first chamber. 4. The device as claimed in claim 3 , wherein the entire second chamber is located further inward radially than the first chamber. 5. The device as claimed in claim 1 , wherein the second fluid channel comprises a syphon. 6. The device as claimed in claim 1 , wherein the compression chamber comprises a fluid inlet and a fluid outlet, the first fluid channel connecting the fluid outlet of the first chamber to the fluid inlet of the compression chamber, and the second fluid channel connecting the fluid outlet of the compression chamber to the fluid inlet of the second chamber. 7. The device as claimed in claim 1 , wherein the compression chamber comprises a fluid opening fluidically coupled to a channel section into which the first fluid channel and the second fluid channel lead. 8. The device as claimed in claim 1 , wherein the first fluid channel comprises a valve which represents a higher flow resistance for a flow of fluid from the first chamber to the compression chamber than in the opposite direction. 9. The device as claimed in claim 1 , wherein the unit for supporting comprises at least one of a pressure source for producing a pressure within the compression chamber, a heat source for heating the compressible medium, and a unit for effecting gas evolution due to chemical reactions. 10. A method of pumping a liquid, comprising: introducing a liquid into a first chamber of a fluidics module, the fluidics module comprising: the first chamber including a fluid outlet; a compression chamber; a second chamber including a fluid inlet; a first fluid channel between the fluid outlet of the first chamber and the compression chamber; a second fluid channel between the compression chamber and the fluid inlet of the second chamber, wherein a liquid may be centrifugally driven through the first fluid channel from the first chamber into the compression chamber, wherein the second fluid channel includes at least one portion whose beginning is located further outward radially than its end, wherein a flow resistance of the second fluid channel for a flow of liquid from the compression chamber to the second chamber is smaller than a flow resistance of the first fluid channel for a flow of liquid from the compression chamber to the first chamber, wherein, upon rotation of the fluidics module, a compressible medium within the compression chamber may be trapped and compressed by a liquid driven from the first chamber into the compression chamber by centrifugal force, and wherein liquid may be driven into the second chamber from the compression chamber through the second fluid channel by a reduction of the rotational frequency and by consequent expansion of the compressible medium, and wherein the compression chamber permits the liquid driven from the first chamber into the compression chamber by centrifugal force to trap and compress the compressible medium in the compression chamber; subjecting the fluidics module to a rotational frequency in order to drive liquid from the first chamber through the first fluid channel into the compression chamber, the compressible medium being trapped and compressed within the compression chamber, and filling levels of the liquid in the first fluid channel, the compression chamber and the second fluid channel adopting a state of equilibrium; and reducing the rotational frequency, the compressible medium within the compression chamber expanding and, thereby, liquid being driven from the compression chamber through the second fluid channel into the second chamber. 11. The method as claimed in claim 10 , further comprising supporting the expansion of the compressible medium upon reduction of the rotational frequency. 12. The method as claimed in claim 11 , wherein supporting comprises at least one of subjecting the compressible medium to a pressure, heating the compressible medium, and effecting gas evolution within the compression chamber.
thermal energy, e.g. vaporisation, bubble jet · CPC title
Venting, avoiding backpressure, avoid gas bubbles · CPC title
Pumps using positively or negatively pressurised fluid medium acting directly on the liquid to be pumped (using only negative pressure F04F3/00; jet pumps F04F5/00; siphons F04F10/00) · CPC title
Disc shape · CPC title
characterised by the means or forces applied to move the fluids · CPC title
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