Bioerodible matrix for tissue involvement

Patent metadata

Field	Value
Publication number	US-10898607-B2
Application number	US-201615373666-A
Country	US
Kind code	B2
Filing date	Dec 9, 2016
Priority date	Mar 27, 2009
Publication date	Jan 26, 2021
Grant date	Jan 26, 2021

Abstract

Disclosed herein are polyurethane polymer matrices with a porosity of from about 20 microns to about 90 microns that are useful in promoting closure and protection of incision sites; supporting the lower pole position of breast implants; and providing a partial or complete covering of breast implants to provide a beneficial interface with host tissue and to reduce the potential for malpositioning or capsular contracture. The disclosed matrices can be seeded with mammalian cells.

First claim

What is claimed is:

1. A medical implant comprising:
a breast prosthesis; and
a matrix on said breast prosthesis, the matrix comprising a resorbable or bioerodible polymer component and a cellular component, wherein the polymer component comprises polycaprolactone soft segments having an amorphous rubbery phase, the matrix having a porosity conducive to cell growth and capable of providing a beneficial interface between the prosthesis and host tissue to enhance biocompatibility and reducing the potential for malpositioning or capsular contracture.

2. The implant of claim 1 wherein the cellular component comprises stem cells.

3. The implant of claim 1 wherein the cellular component comprises adipose cells.

4. The implant of claim 1 wherein the cellular component comprises stem cells and adipose cells.

5. The implant of claim 1 wherein the matrix forms at least a partial covering on said breast prosthesis.

6. The implant of claim 1 wherein the matrix forms a complete covering of said breast prosthesis.

7. The implant of claim 1 wherein the matrix has a pore size diameter of about 10 to about 1000 microns.

8. The implant of claim 1 wherein the matrix has a pore size diameter of from about 20 to about 90 microns.

Assignees

• Allergan Inc

Inventors

• Van Epps Dennis E
• Powell Thomas E

Classifications

• A61L27/3604

  characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L27/3886

  comprising two or more cell types · CPC title

• A61F2/12

  Mammary prostheses · CPC title

• A61L27/3804

  characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells · CPC title