Porogen compositions, methods of making and uses

Patent metadata

Field	Value
Publication number	US-9593224-B2
Application number	US-201414504329-A
Country	US
Kind code	B2
Filing date	Oct 1, 2014
Priority date	Sep 28, 2010
Publication date	Mar 14, 2017
Grant date	Mar 14, 2017

Abstract

Provided are porogen compositions and methods of using such porogen compositions in the manufacture of porous materials, for example, porous silicone elastomers. The porogens generally include comprising a core material and shell material different from the core material. The porogens can be used to form a scaffold for making a resulting porous elastomer when the scaffold is removed.

First claim

What is claimed is:

1. A method for making an article including a porous elastomeric surface, the method comprising the steps of:
a) coating a mandrel with an elastomer;
b) curing the elastomer to form a cured elastomer base layer on the mandrel;
c) coating the cured elastomer base layer with additional elastomer;
d) coating the additional elastomer with porogens to form an elastomer coated porogen mixture on the cured elastomer base layer, the porogens comprising a shell material and a core material, wherein the shell material has a melting temperature that is lower than a melting temperature of the core material;
e) treating the elastomer coated porogen mixture to form a porogen scaffold comprising fused porogens and cured elastomer, wherein the fused porogens are each connected to at least four other fused porogens, and wherein the diameter of substantially all the connections between each fused porogen is between about 15% to about 80% of a mean porogen diameter; and
f) removing the fused porogens from the cured elastomer, wherein fused porogen removal results in a porous material comprising a non-degradable, biocompatible, elastomer matrix defining an array of interconnected pores.

2. The method of claim 1 , wherein steps (b) and (c) are repeated at least once.

3. The method of claim 1 , wherein steps (b) and (c) are repeated at least repeated twice.

4. The method of claim 1 , wherein the core material is a sugar and the shell material is polyethylene glycol.

Assignees

• Allergan Inc

Inventors

• Liu Futian
• Manesis Nicholas J
• Yu Xiaojie
• Chan Athene Wan Chie

Classifications

• B05D5/00

  Processes for applying liquids or other fluent materials to surfaces to obtain special surface effects, finishes or structures · CPC title

• C08J2205/05

  Open cells, i.e. more than 50% of the pores are open · CPC title

• B01D2239/1216

  Pore size · CPC title

• C08J2383/04

  Polysiloxanes · CPC title

• C08J2201/0422

  containing oxygen atoms, e.g. saccharose · CPC title