Modified polyisobutylene-based polymers, methods of making, and medical devices

Patent metadata

Field	Value
Publication number	US-10882945-B2
Application number	US-201916359079-A
Country	US
Kind code	B2
Filing date	Mar 20, 2019
Priority date	Mar 26, 2018
Publication date	Jan 5, 2021
Grant date	Jan 5, 2021

Abstract

A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

First claim

The invention claimed is:

1. A modified polyisobutylene-based polymer comprising urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments comprise diisocyanate residues and optionally chain extender residues; wherein the phenoxy-containing polyisobutylene residues are derived from a phenoxy-containing polyisobutylene diol, diamine, or combination thereof.

2. The modified polyisobutylene-based polymer of claim 1 comprising urethane groups.

3. A modified polyisobutylene-based polymer comprising urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments comprise diisocyanate residues and chain extender residues.

4. A modified polyisobutylene-based polymer comprising urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments comprise diisocyanate residues and optionally chain extender residues; wherein the weight ratio of soft segments to hard segments is within a range of 90:10 to 10:90.

5. The modified polyisobutylene-based polymer of claim 1 further comprising additional soft segment residues.

6. The modified polyisobutylene-based polymer of claim 5 wherein the weight ratio of phenoxy-containing polyisobutylene residues to additional soft segment residues is within a range of 99:1 to 1:99.

7. The modified polyisobutylene-based polymer of claim 1 having a weight average molecular weight of 10,000 Daltons to 2,000,000 Daltons, as determined by gel permeation chromatography with multiangle laser light scattering detection.

8. A medical device comprising a polymeric region comprising a modified polyisobutylene-based polymer comprising urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments comprise diisocyanate residues and optionally chain extender residues.

9. The medical device of claim 8 comprising an implantable electrical lead, an implantable electrical pulse generator, or an implantable mechanical device.

10. The medical device of claim 9 comprising an implantable electrical lead.

11. The medical device of claim 8 wherein the polymeric region further comprises a therapeutic agent.

12. A method of making the modified polyisobutylene-based polymer comprising phenoxy-containing polyisobutylene residues of claim 1 , the method comprising combining reactants comprising a diisocyanate, an optional chain extender, a phenoxy-containing polyisobutylene diol, damine, or combination thereof, and an optional additional soft segment-containing diol, diamine, or combination thereof under conditions effective to form the modified polyisobutylene-based polymer comprising phenoxy-containing polyisobutylene residues.

13. A method of making the modified polyisobutylene-based polymer comprising phenoxy-containing polyisobutylene resides of claim 3 , the method comprising combining reactants comprising a diisocyanate, a chain extender, a phenoxy-containing polyisobutylene diol, diamine, or combination thereof, and an optional additional soft segment-containing diol, diamine, or combination thereof under conditions effective to form the modified polyisobutylene-based polymer comprising phenoxy-containing polyisobutylene residues.

14. A method of making the modified polyisobutylene-based polymer comprising phenoxy-containing polyisobutylene residues of claim 4 , the method comprising combining reactants comprising a diisocyanate, an optional chain extender, a phenoxy-containing polyisobutylene diol, damine, or combination thereof, and an optional additional soft segment-containing diol, diamine, or combination thereof under conditions effective to form the modified polyisobutylene-based polymer comprising phenoxy-containing polyisobutylene residues.

15. The modified polyisobutylene-based polymer of claim 1 wherein the phenoxy-containing polyisobutylene residues are derived from a phenoxy-containing polyisobutylene compound of the following formula:

wherein R 1 is an initiator residue, each X is independently —OH, —NH 2 , or —NHR 2 , each r is independently 1-20, n=1-500, and m=1-500.

16. The modified polyisobutylene-based polymer of claim 1 wherein the phenoxy-containing polyisobutylene residues are derived from a phenoxy-containing polyisobutylene diol of the following formula:

wherein R 1 is an initiator residue, each r is independently 1-20, n=1-500, and m=1-500.

17. The modified polyisobutylene-based polymer of claim 1 wherein the phenoxy-containing polyisobutylene residues are derived from a phenoxy-containing polyisobutylene diol of the following formula:

wherein each r (independently)=1-20, n=1-500, and m=1-500.

18. The medical device of claim 8 , wherein the phenoxy-containing polyisobutylene residues are derived from a phenoxy-containing polyisobutylene diol, diamine, or combination thereof.

19. The medical device of claim 8 , wherein the phenoxy-containing polyisobutylene residues are derived from a phenoxy-containing polyisobutylene compound of the following formula:

wherein R 1 is an initiator residue, each X is independently —OH, —NH 2 , or —NHR 2 , each r is independently 1-20, n=1-500, and m=1-500.

20. A modified polyisobutylene-based polymer comprising urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments comprise diisocyanate residues and optionally chain extender residues; wherein the phenoxy-containing polyisobutylene residues include oxygen atoms that are not part of a urethane or urethane-urea group, if present.

Assignees

• Medtronic Inc

Inventors

• Chaffin Kimberly A
• Chen Xiangji
• Jolly Matthew
• Lyu Suping
• Thor Peter L
• Untereker Darrel F
• Wang Zhaoxu

Classifications

• A61N1/36071

  Pain · CPC title

• A61B5/6847

  mounted on an invasive device · CPC title

• A61B5/14503

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors (A61B5/1459, A61B5/1464, A61B5/1473, A61B5/1482, A61B5/14865 take precedence) · CPC title

• A61B2562/12

  Manufacturing methods specially adapted for producing sensors for in-vivo measurements · CPC title

• A61N1/362

  Heart stimulators (heart defibrillators A61N1/39) · CPC title