Methods and compositions for treating viral diseases

Patent metadata

Field	Value
Publication number	US-10869873-B2
Application number	US-201615150293-A
Country	US
Kind code	B2
Filing date	May 9, 2016
Priority date	Dec 6, 2011
Publication date	Dec 22, 2020
Grant date	Dec 22, 2020

Abstract

The invention provides a method for treating viral infections and coinfections through the use of inhibitory agents that prevent a unique viral structural protein motifs from binding to host proteins from the clathrin adaptor proteins family and subsequently preventing viral replication.

First claim

The invention claimed is:

1. A method of inhibiting assembly or budding of Dengue virus, comprising contacting a host cell that is infected with Dengue virus with sunitinib or a pharmaceutically acceptable salt of sunitinib, wherein the sunitinib inhibits adaptor-associated kinase 1 (AAK1), thereby inhibiting assembly or budding of the Dengue virus.

2. The method of claim 1 , wherein said sunitinib or pharmaceutically acceptable salt of sunitinib blocks binding of a viral structural protein to a host protein.

3. The method of claim 1 , wherein said sunitinib or pharmaceutically acceptable salt of sunitinib competes with a viral structural protein for binding to a host protein.

4. The method of claim 1 , wherein said sunitinib or pharmaceutically acceptable salt of sunitinib competes with a host protein for binding to a viral structural protein.

5. The method of claim 1 , further comprising contacting said host cell with erlotinib, midostaurin, or a pharmaceutically acceptable salt or combination thereof.

6. The method of claim 5 , wherein the host cell is contacted with erlotinib or a pharmaceutically acceptable salt of erlotinib.

7. The method of claim 5 , wherein the host cell is contacted with midostaurin or a pharmaceutically acceptable salt of midostaurin.

8. The method of claim 1 , wherein assembly or budding of said Flaviviridae is inhibited.

Assignees

• Univ Leland Stanford Junior

Inventors

• Einav Shirit
• Barouch-Bentov Rina
• Neveu Gregory
• Zivav Amotz

Classifications

• G01N2500/10

  involving cells · CPC title

• A61K31/553 Primary

  having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine · CPC title

• A61K31/404

  Indoles, e.g. pindolol · CPC title

• C12C1/18

  Preparation of malt extract or of special kinds of malt, e.g. caramel, black malt (malt products for use as foodstuffs A23L) · CPC title

• A61K31/517

  ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine · CPC title