Placental tissue component compositions for treatment of skin defects and methods using same

Patent metadata

Field	Value
Publication number	US-10849933-B2
Application number	US-201916416875-A
Country	US
Kind code	B2
Filing date	May 20, 2019
Priority date	May 18, 2018
Publication date	Dec 1, 2020
Grant date	Dec 1, 2020

Abstract

The present disclosure provides methods of treating defects such as wrinkles or scars via a subdermal injection of placental tissue components. It also provides placental tissue compositions maintained within the barrel of a syringe, which may be for use in treating such defects.

First claim

What is claimed is:

1. A placental tissue composition in an injectable form, said placental tissue composition comprising an effective amount of placental tissue components; wherein the placental tissue components comprise particles of decellularized placental disc and at least one of amniotic membrane, chorionic membrane, and umbilical cord.

2. The composition of claim 1 , comprising particles of amniotic membrane.

3. The composition of claim 1 , comprising particles of chorionic membrane.

4. The composition of claim 1 , comprising particles of amniotic membrane and chorionic membrane.

5. The composition of claim 1 , comprising particles of umbilical cord.

6. The composition of claim 1 , comprising particles of amniotic membrane, chorionic membrane, and umbilical cord.

7. The composition of claim 1 , wherein the particles are rehydrated.

8. The composition of claim 1 , wherein said particles are micronized.

9. The composition of claim 1 , wherein the placental tissue components comprise about 1-20% dehydrated amniotic membrane and/or chorionic membrane particles if present, about 1-30% dehydrated umbilical cord particles if present, and about 50-98% dehydrated, decellularized placental disc particles, by weight.

10. The composition of claim 1 , for use in treating a scar or a wrinkle.

11. A method of treating a defect in a patient by injecting a placental tissue composition comprising placental tissue components at the site of the defect; wherein the placental tissue components comprise particles of decellularized placental disc and at least one of amniotic membrane, chorionic membrane, and umbilical cord.

12. The method of claim 11 , wherein the composition comprises particles of amniotic membrane.

13. The method of claim 11 , wherein the composition comprises particles of chorionic membrane.

14. The method of claim 11 , wherein the composition comprises particles of amniotic membrane and chorionic membrane.

15. The method of claim 11 , wherein the composition comprises particles of umbilical cord.

16. The method of claim 11 , wherein the composition comprises particles of amniotic membrane, chorionic membrane, and umbilical cord.

17. The method of claim 11 , wherein the particles are rehydrated.

18. The method of claim 11 , wherein the particles are micronized.

19. The method of claim 11 , wherein the defect is selected from the group consisting of scars and wrinkles.

20. The method of claim 11 , wherein the placental tissue components comprise about 1-20% dehydrated amniotic membrane and/or chorionic membrane particles if present, about 1-30% dehydrated umbilical cord particles if present, and about 50-98% dehydrated, decellularized placental disc particles, by weight.

Assignees

• Mimedx Group Inc

Inventors

• Levaughn Rick
• Arjunon Sivakkumar
• Taylor Olivia

Classifications

• A61Q19/08

  Anti-ageing preparations · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61K8/982

  Reproductive organs; Embryos, Eggs · CPC title

• A61K35/50 Primary

  Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells · CPC title

• A61K35/51

  Umbilical cord; Umbilical cord blood; Umbilical stem cells · CPC title