Glucose-responsive artificial muscle and manufacturing method therefor

Patent metadata

Field	Value
Publication number	US-10849733-B2
Application number	US-201716073001-A
Country	US
Kind code	B2
Filing date	Jan 26, 2017
Priority date	Jan 29, 2016
Publication date	Dec 1, 2020
Grant date	Dec 1, 2020

Abstract

The present invention relates to a glucose-reactive artificial muscle, and more particularly, to a carbon nanotube, a hydrogel-based glucose-reactive artificial muscle which has a reversible volume change due to variations in glucose concentration, a method of forming the same, a rotary artificial muscle using the same, and a method of detecting glucose. The glucose-reactive artificial muscle according to the present invention may sense variations in glucose concentration with high sensitivity within a short time by providing reversible twisting using the swelling and shrinkage of hydrogels, which occur due to a change in internal anionic charges, caused by the bonding between a boronic acid introduced to the hydrogels and glucose.

First claim

The invention claimed is:

1. A glucose-reactive hydrogel-based artificial muscle, comprising:
a multi-layered carbon nanotube (CNT) sheet; and
hydrogels embedded in the surface of the CNT sheet,
wherein the artificial muscle is a fiber in which the hydrogel-embedded CNT sheet is twisted, and
the hydrogel has a reversible volume change by the reaction with glucose.

2. The artificial muscle according to claim 1 , wherein the artificial muscle has a twisted or coiled structure.

3. The artificial muscle according to claim 1 , wherein the hydrogels are boronic acid-conjugated hyaluronic acid/cholesterol nanogels, represented by Formula 1 below:

wherein n is an integer of 2 to 20000, and each of a and b is an integer of 1 to 10000.

4. The artificial muscle according to claim 1 , wherein the hydrogels are embedded at a content of 80 to 99 wt % with respect to the total content of the hydrogel-embedded CNT sheet.

5. The artificial muscle according to claim 1 , wherein the glucose concentration ranges from 1 to 100 mM.

6. A glucose-reactive, rotary artificial muscle, comprising:
a fiber-type artificial muscle unit including the glucose-reactive hydrogel-based artificial muscle according claim 1 ; and
a fiber-type scaffold unit formed by twisting a multi-layered CNT sheet,
wherein one end of the fiber-type artificial muscle unit is connected with one end of the fiber-type scaffold unit by a paddle, and
the other end of the fiber-type artificial muscle unit and the other end of the fiber-type scaffold unit are each independently fixed using fixing devices.

7. The rotary artificial muscle according to claim 6 , wherein the fiber-type artificial muscle unit and the fiber-type scaffold unit are twisted in the same twisting direction so as to have a twisted or coiled structure.

8. The rotary artificial muscle according to claim 6 , wherein the fiber-type artificial muscle unit is reversibly expanded or shrunk in volume by the reaction with glucose in such a manner that the fiber-type scaffold unit is rotated.

Assignees

• Univ Hanyang Ind Univ Coop Found

Inventors

• Kim Seon Jeong
• Ko Sachan

Classifications

• A61F2002/0894

  Muscles · CPC title

• C08K3/041

  Carbon nanotubes · CPC title

• C08L5/08

  Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title

• C08B37/0072

  Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates · CPC title

• C08L43/00

  Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing boron, silicon, phosphorus, selenium, tellurium or a metal; Compositions of derivatives of such polymers (of metal salts, e.g. phenolates, alcoholates, see the parent compounds) · CPC title