Propyl gallate-containing vitamin preparations

Patent metadata

Field	Value
Publication number	US-10835456-B2
Application number	US-201716316802-A
Country	US
Kind code	B2
Filing date	Jul 17, 2017
Priority date	Jul 19, 2016
Publication date	Nov 17, 2020
Grant date	Nov 17, 2020

Abstract

The present invention relates to a pulverulent vitamin formulation in which the vitamin essentially has a particle size of less than 0.7 μm and which comprises an effective amount of propyl gallate, and also to processes for producing this formulation, and to formulations obtainable by these processes and to the use thereof as animal feed, food, food supplement, personal care product or pharmaceutical composition. The formulations of the invention have improved stability compared to the prior art.

First claim

The invention claimed is:

1. A pulverulent vitamin formulation in which the vitamin has a particle size of less than 0.7 μm, wherein said formulation comprises 3.5% to 9.5% by weight of propyl gallate based on the total amount of the formulation, to stabilize the vitamin in the formulation and wherein the formulation is adjusted to a pH from 6.5 to 8.5.

2. The pulverulent vitamin formulation according to claim 1 , where the weight ratio of propyl gallate to vitamin in the formulation is between 0.21 and 2.63.

3. The pulverulent vitamin formulation according to claim 1 , wherein the vitamin is selected from the group consisting of vitamins D, E, K, Q derivatives thereof, coenzyme Q10 and carotenoids.

4. The pulverulent vitamin formulation according to claim 1 , wherein the formulation comprises butylhydroxytoluene or synthetic and/or natural tocopherol.

5. The pulverulent vitamin formulation according to claim 4 , wherein the tocopherol is natural tocopherol.

6. The pulverulent vitamin formulation according to claim 4 , wherein propyl gallate and tocopherol are present in the formulation in a ratio of 9:1 to 1:2.

7. The pulverulent vitamin formulation according to claim 4 , wherein propyl gallate and butylhydroxytoluene are present in the formulation in a ratio of 8:1 to 1:4.

8. The pulverulent vitamin formulation according to claim 1 , wherein the quotient therein of active vitamins A2/A1 in relation to a comparative sample that comprises, rather than propyl gallate, the same amount of ethoxyquin B2/B1, after 4 weeks in a stress test, is at least 0.75, where the proportion of active vitamin is ascertained by weighing, 100 mg in each case of the formulation produced and 4 g of a mixture, of 50% by weight of fine lime having a particle size <1000 μm, 20% by weight of wheat bran having a particle size <1000 μm, 20% by weight of 50% silica-supported choline chloride having a particle size <1000 μm and 10% by weight of a trace element mixture having a particle size of 100-500 μm, said trace element mixture consisting of 46.78% by weight of FeSO 4x 7H 2 O having a particle size of 100-500 μm, 37.43% by weight of CUSO 4x 5H 2 O having a particle size of 100-500 μm, 11.79% by weight of ZnO having a particle size <500 μm, 3.61% by weight of MnO and 0.39% by weight of CoCO 3 , into 50 mL glass containers, mixing the ingredients and storing them in a climate-controlled chamber at 40° C. and 70% humidity for 4 weeks, with determination of the vitamin contents A1 and B1 prior to commencement of the storage and of the vitamin contents A2 and B2 on conclusion of the storage and calculating the proportion of active vitamins from the quotients A2/A1 and B2/B1.

9. An animal feed, food, food supplement, personal care product or pharmaceutical composition comprising the pulverulent vitamin formulation according to claim 1 .

10. The pulverulent vitamin formulation according to claim 1 , wherein the vitamin is selected from the group consisting of vitamin E esters, tocotrienol, vitamin K1, vitamin K2, coenzyme Q10, (β-carotene, canthaxanthin, citranaxanthin, astaxanthin and ester derivatives, zeaxanthin and ester derivatives, lutein and ester derivatives, lycopene, apocarotenic acid and ester derivatives, apocarotenal and mixtures thereof.

11. The pulverulent vitamin formulation according to claim 1 , wherein the vitamin is selected from the group consisting of (β-carotene, canthaxanthin, citranaxanthin, and C30 ester derivatives.

Assignees

• Basf Se

Inventors

• Meyer-Boehm Kathrin
• Helgason Thrandur
• Singh Raajvinder
• Dobler Walter
• Schording Peter
• Wigbers Christof Wilhelm
• Kolter Karl
• Bruhns Stefan
• Pelletier Wolf
• Wagner Daniel

Classifications

• A61K31/05

  Phenols {(cannabinoids A61K31/658)} · CPC title

• A61K8/67

  Vitamins · CPC title

• A61K31/235

  having an aromatic ring attached to a carboxyl group · CPC title

• A61K2800/52

  Stabilizers · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title