Gel capsule containing sterol and solubilising agent

Patent metadata

Field	Value
Publication number	US-10188133-B2
Application number	US-201615568493-A
Country	US
Kind code	B2
Filing date	Apr 20, 2016
Priority date	Apr 23, 2015
Publication date	Jan 29, 2019
Grant date	Jan 29, 2019

Abstract

The present invention relates to gel capsules comprising sterol and solubilizer for use as food supplement or as pharmaceutical.

First claim

The invention claimed is:

1. A formulation for gel capsules comprising at least 61% by weight sterol ester and at least two solubilizers selected from the group consisting of polysorbates, lecithins, sodium stearoyl-2-lactylates, fatty acid esters of ascorbic acid, fatty acid esters of isoascorbic acid, and sugar esters with fatty acids.

2. The formulation according to claim 1 , wherein the sterol ester has been obtained from sterols of plant origin (phytosterols) or the hydrogenated analogs thereof, the stanols.

3. The formulation according to claim 2 , wherein the sterol ester has been obtained from sterols.

4. The formulation according to claim 1 , wherein the sterol ester is obtained by esterification of fatty acids of natural origin.

5. The formulation according to claim 4 , wherein the fatty acids are monounsaturated or polyunsaturated fatty acids.

6. The formulation according to claim 5 , wherein the fatty acids comprise omega-3 fatty acids in an amount of at least 30 percent by weight, based on the fatty acid portion.

7. The formulation according to claim 1 , wherein, at least one of the at least two solubilizers is selected from the group consisting of polysorbates, lecithins, sodium stearoyl-2-lactylates, and combinations thereof.

8. The formulation according to claim 7 , comprising at least one wherein at least one of the at least two solubilizers is selected from the group consisting of fatty acid esters of ascorbic acid, fatty acid esters of isoascorbic acid, and sugar esters with fatty acids.

9. The formulation according to claim 1 , wherein the at least two solubilizers are selected from the group consisting of ascorbyl fatty acid ester, lecithin, and polysorbate.

10. The formulation according to claim 1 , wherein the formulation comprises water or oil, and wherein, the water or oil is present in an amount of not more than 15% by weight, based on the formulation.

11. A gel capsule comprising the formulation according to claim 1 .

12. The gel capsule according to claim 11 in the form of a soft or hard capsule.

13. The gel capsule according to claim 11 for use as food supplement or as pharmaceutical.

14. A process for producing a formulation according to claim 1 , comprising:
(a) combining sterol ester and the at least two solubilizers to form a mixture,
(b) heating the mixture to a temperature above the melting point of the sterol ester, and
(c) mixing the heated mixture at 500 to 2500 rpm for 1 to 60 minutes to obtain a uniform mixture.

15. A process for producing a gel capsule according to claim 11 , comprising:
(a) combining sterol ester and the at least two solubilizers to form a mixture,
(b) heating the mixture to a temperature above the melting point of the sterol ester, and
(c) mixing the heated mixture at 500 to 2500 rpm for 1 to 60 minutes to obtain a uniform mixture; and
(d) incorporating the uniform mixture into a gel capsule.

16. The formulation according to claim 1 , wherein the sterol ester is obtained by esterification of fatty acids of plant or marine origin.

17. The formulation according to claim 8 , comprising ascorbyl palmitate, lecithin and polysorbate 80.

18. The formulation according to claim 1 , wherein the at least two solubilizers are lecithin and polysorbate.

19. The formulation according to claim 18 , wherein the polysorbate is polysorbate 80.

Assignees

• Basf Se

Inventors

• Gierke Juergen
• Weidner Martin
• Heer Marianne
• Schmeller Thorsten
• Helgason Thrandur
• Bohn Heribert
• Weiland Anja

Classifications

• A61P3/02

  Nutrients, e.g. vitamins, minerals · CPC title

• A61K31/56

  Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23P10/30

  Encapsulation of particles, e.g. foodstuff additives · CPC title

• A23L33/12

  Fatty acids or derivatives thereof · CPC title