Compounds that modulate fatty acid receptor activity and pet food products containing the same

Patent metadata

Field	Value
Publication number	US-10827772-B2
Application number	US-201515534421-A
Country	US
Kind code	B2
Filing date	Dec 10, 2015
Priority date	Dec 10, 2014
Publication date	Nov 10, 2020
Grant date	Nov 10, 2020

Abstract

A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a GPR120 fatty acid receptor that can be used to enhance the fatty acid taste and/or palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.

First claim

We claim:

1. A flavor composition for a cat food product comprising a compound of Formula II:

wherein
X is (C)R 1 R 2 , O, S, C(O), or a chemical bond;
X 1 is (C)R 1 R 2 , O, S, or N(R 1 );
Y is COOH, SO 3 H, —OP(O)(OH) 2 , or Tetrazole;
W is halogen, COOH, COOMe, CN, N(R 1 )(R 2 ), CHO, CONR 1 R 2 , Aryl, OH, H, —S-Aryl, —O-Aryl, —N-Aryl, CF 3 , OCH 3 , CH 3 , NO 2 , or OEt;
Z 1 and Z 2 are each independently selected from halogen, COOH, COOMe, CN, N(R 1 )(R 2 ), CHO, CONR 1 R 2 , Aryl, OH, H, —S-Aryl, —O-Aryl, —N-Aryl, CF 3 , OCH 3 , CH 3 , NO 2 , and OEt;
R 1 and R 2 are each independently selected from H and branched or unbranched C 1 -C 6 lower alkyl;
n 1 is 0-4;
n 2 is 0-2; and
n 3 is 0-4,
wherein the compound is present in the flavor composition at a concentration of from about 0.001 μM to about 1 mM, wherein the compound is a feline GPR 120 agonist, and wherein the compound increases a fatty acid taste of the cat food product.

2. The flavor composition of claim 1 , wherein the compound is selected from the group consisting of 3-(4-((4-fluoro-4′-methylbiphenyl-2-yl)methoxy)phenyl)propanoic acid, and 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid.

3. A cat food product comprising the flavor composition of claim 1 , wherein the flavor composition is present in an amount effective to increase the palatability of the food product, as determined by a panel of taste testers.

4. The cat food product of claim 3 , wherein the flavor composition is present at a concentration of from about 0.001% to about 10% w/w in the cat food product.

5. The cat food product of claim 3 , wherein the cat food product is a wet pet food product.

6. The cat food product of claim 3 , wherein the cat food product is a dry pet food product.

7. A method of increasing a fatty acid taste intensity in a cat food product comprising admixing a cat food product with a flavor composition comprising a compound represented by Formula II:

wherein
X is (C)R 1 R 2 , O, S, C(O), or a chemical bond;
X 1 is (C)R 1 R 2 , O, S, or N(R 1 );
Y is COOH, SO 3 H, —OP(O)(OH) 2 , or Tetrazole;
W is halogen, COOH, COOMe, CN, N(R 1 )(R 2 ), CHO, CONR 1 R 2 , Aryl, OH, H, —S-Aryl, —O-Aryl, —N-Aryl, CF 3 , OCH 3 , CH 3 , NO 2 , or OEt;
Z 1 and Z 2 are each independently selected from halogen, COOH, COOMe, CN, N(R 1 )(R 2 ), CHO, CONR 1 R 2 , Aryl, OH, H, —S-Aryl, —O-Aryl, —N-Aryl, CF 3 , OCH 3 , CH 3 , NO 2 , and OEt;
R 1 and R 2 are each independently selected from H and branched or unbranched C 1 -C 6 lower alkyl;
n 1 is 0-4;
n 2 is 0-2; and
n 3 is 0-4;
wherein the compound is present in the flavor composition at a concentration of from about 0.001 μM to about 1mM, wherein the compound is a feline GPR 120 agonist, and wherein the compound increases a fatty acid taste of the cat food product.

8. The method of claim 7 , wherein the flavor composition is present at a concentration of from about 0.001% to about 10% w/w in the cat food product.

Assignees

• Mars Inc

Inventors

• Mcgrane Scott Joseph
• Gibbs Matthew Ronald
• Fine Richard Masten
• Skiles Jerry Wallace

Classifications

• A23K20/111 Primary

  Aromatic compounds · CPC title

• A23K50/40

  for carnivorous animals, e.g. cats or dogs · CPC title

• A23K20/153

  Nucleic acids; Hydrolysis products or derivatives thereof · CPC title

• A23L27/204

  Aromatic compounds · CPC title

• A23K20/142

  Amino acids; Derivatives thereof · CPC title