Thioamide-modified peptides and uses thereof
US-11891425-B2 · Feb 6, 2024 · US
Use of particular combinations of carbohydrates for stabilizing proteins, and protein compositions containing such combinations
US10822372B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10822372-B2 |
| Application number | US-201615563871-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 30, 2016 |
| Priority date | Apr 3, 2015 |
| Publication date | Nov 3, 2020 |
| Grant date | Nov 3, 2020 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
One subject of the present invention is the use of a combination of a polyol (i) consisting of 12 carbon atoms and of a polyol (ii) consisting of 4 to 6 carbon atoms, as protein stabilizer. Another subject of the present invention is protein compositions comprising such a combination. A final subject of the present invention is a process for preparing protein compositions using such a combination.
First claim
Opening claim text (preview).
The invention claimed is: 1. A process of stabilizing proteins, comprising adding to a protein to be stabilized a combination of a polyol (i) consisting of 12 carbon atoms and of a polyol (ii) consisting of 4 to 6 carbon atoms, wherein said protein to be stabilized is a therapeutic protein selected from the group consisting of enzymes, cytokines, hormones, growth factors, plasma factors, vaccines, and antibodies, or is an enzyme intended for industrial use, and subjecting said protein to be stabilized to at least one of cryogenization, lyophilization treatments, and storage, wherein the polyol (i) is maltitol, and wherein a dry weight ratio of said polyol (i) to said polyol (ii) ranges from 50/50 to 75/25. 2. The process according to claim 1 , wherein said polyol (ii) comprises at least one of sorbitol, xylitol, and mannitol. 3. A process for preparing a protein composition comprising mixing together a protein, a polyol (i) consisting of 12 carbon atoms, and of a polyol (ii) consisting of 4 to 6 carbon atoms, wherein said protein is a therapeutic protein selected from the group consisting of enzymes, cytokines, hormones, growth factors, plasma factors, vaccines, and antibodies, or is an enzyme intended for industrial use, and subjecting said protein composition to at least one of cryogenization, lyophilization treatments, and storage, wherein the polyol (i) is maltitol, and wherein a dry weight ratio of said polyol (i) to said polyol (ii) ranges from 50/50 to 75/25. 4. The process according to claim 1 , wherein said protein to be stabilized is selected from the group consisting of erythropoietin, insulin, monoclonal antibodies, and growth hormones. 5. The process according to claim 1 , wherein said protein to be stabilized is a β-amylase.
Assignees
Inventors
Classifications
- C07K1/1136Primary
by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents · CPC title
hydrolysing O- and S- glycosyl compounds (3.2.1) · CPC title
Beta-amylase (3.2.1.2) · CPC title
Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents · CPC title
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US10822372B2 cover?
- One subject of the present invention is the use of a combination of a polyol (i) consisting of 12 carbon atoms and of a polyol (ii) consisting of 4 to 6 carbon atoms, as protein stabilizer. Another subject of the present invention is protein compositions comprising such a combination. A final subject of the present invention is a process for preparing protein compositions using such a combination.
- Who is the assignee on this patent?
- Roquette Freres
- What technology area does this patent fall under?
- Primary CPC classification C07K1/1136. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Nov 03 2020 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).