Stabilized p53 peptides and uses thereof
US-2015119551-A1 · Apr 30, 2015 · US
Stabilized alpha helical peptides and uses thereof
US9464115B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9464115-B2 |
| Application number | US-201314070354-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 1, 2013 |
| Priority date | Nov 5, 2003 |
| Publication date | Oct 11, 2016 |
| Grant date | Oct 11, 2016 |
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Abstract
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Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
First claim
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The invention claimed is: 1. A cell-penetrable cross-linked polypeptide of Formula (I): wherein: each R 1 and R 2 are independently H, C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, arylalkyl, cycloalkylalkyl, heteroarylalkyl, or heterocyclylalkyl; wherein at least either R 1 or R 2 is C 1 -C 20 alkyl, C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, arylalkyl,…
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- What does patent US9464115B2 cover?
- Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
- Who is the assignee on this patent?
- Dana Farber Cancer Inst Inc, Harvard College
- What technology area does this patent fall under?
- Primary CPC classification C07K14/4747. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Oct 11 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).